Opposite role of delta 1- and delta 2-opioid receptors activated by endogenous or exogenous opioid agonists on the endogenous cholecystokinin system: further evidence for delta-opioid receptor heterogeneity

Neuroscience
F NobleB P Roques

Abstract

Using the mouse caudate-putamen, where delta-opioid receptor subtypes have been shown to regulate adenylyl cyclase activity, we show in this study that endogenous enkephalins inhibit enzyme activity through activation of delta 1- and delta 2-opioid receptors. Thus, naltriben or 7-benzylidenenaltrexone as well as the delta-selective antagonist naltrindole (mixed delta 1 and delta 2 antagonist) antagonized inhibition of adenylyl cyclase activity induced by methionine- or leucine-enkephalin, while the micro-antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) was without effect. Furthermore, we have previously shown that activation of delta-opioid receptors increases cholecystokinin release in the central nervous system, resulting in a potentiation of micro-opioid antinociceptive responses, and the respective role of delta 1- and delta 2-opioid receptors in this facilitatory effect has now been evaluated. Activation of delta 2-opioid receptors, either by endogenous enkephalins protected from catabolism by the complete enkephalin-degrading enzyme inhibitor N-((R,S)-2-benzyl-3((S)(2-amino-4-methyl-thio) butyldithio)-1-oxopropyl)-L-phenyl-alanine benzyl ester (RB 101), or by the delta 2-selective agonist Tyr-D-Ser(O-tert-butyl)-...Continue Reading

References

Jul 21, 1992·European Journal of Pharmacology·P S PortogheseA E Takemori
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B L KiefferC G Hirth
Dec 28, 1992·Science·C J EvansR H Edwards
Jun 26, 1992·Journal of Medicinal Chemistry·M C Fournié-ZaluskiB P Roques
Oct 4, 1989·European Journal of Pharmacology·J S HeymanF Porreca
Jul 3, 1989·FEBS Letters·R E Rodríguez, M P Sacristán
Jan 27, 1988·European Journal of Pharmacology·P S PortogheseA E Takemori
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R S Chang, V J Lotti
Nov 5, 1985·European Journal of Pharmacology·G WaksmanB Roques
Nov 21, 1980·European Journal of Pharmacology·N M LeeH H Loh
Jul 20, 1984·European Journal of Pharmacology·M C Fournie-ZaluskiB P Roques
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K YasudaG I Bell

❮ Previous
Next ❯

Citations

Mar 14, 2001·European Journal of Pharmacology·J MikaB Przewłocka
Feb 12, 1999·Brain Research. Developmental Brain Research·A LaferrièreI R Moss
Mar 26, 1999·Trends in Neurosciences·M G Darlison, D Richter
Jan 1, 1997·Peptides·G A OlsonA J Kastin
May 8, 1998·Journal of Pineal Research·M EbadiR J Reiter
Jun 28, 2016·Pharmacological Reviews·Louis GendronGraciela Pineyro
Aug 7, 2009·Cell Metabolism·Grace W C CheungTony K T Lam
May 28, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Aet Alttoa, Jaanus Harro
May 10, 2011·European Journal of Pharmacology·Deysi Y Bermúdez-OcañaIsela Esther Juárez-Rojop
Mar 18, 1999·Progress in Neurobiology·L H LazarusS Salvadori

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.