OPRM1 influence on and effectiveness of an individualized treatment plan for prescription opioid use disorder patients

Annals of the New York Academy of Sciences
Javier MurielAna M Peiró

Abstract

Screening for opioid use disorder should be considered in chronic non-cancer pain (CNCP) patients with long-term use of opioids. The aim of our study was to assess the effectiveness of an individualized treatment plan (ITP) for prescription opioid dependence that included screening of pharmacogenetic markers. An observational prospective study was performed using prescription opioid-dependent CNCP outpatients (n = 88). Patients were divided into nonresponders, responders, or high responders according to their response to the ITP. Genotyping of OPRM1 (A118G), OPRD1 (T921C), COMT (G472A), ABCB1 (C3435T), and ARRB2 (C8622T) was performed by real-time PCR. Our ITP achieved a significant reduction of the morphine equivalent daily dose (MEDD) in 64% of responders, including 33% of high responders. Nonopioid medication or buprenorphine use was significantly higher at final versus basal visit. 118-AA OPRM1 patients required significantly lower MEDD at basal and final visits. Our ITP showed effectiveness and security in reducing MEDD in opioid-dependent patients, with good conversion to buprenorphine that was more pronounced in 118-AA OPRM1 patients.

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Citations

Nov 21, 2019·The Pharmacogenomics Journal·Beatriz PlanellesAna M Peiró
Apr 29, 2020·Scientific Reports·Ilaria ErbiDaniele Campa
Dec 15, 2018·Basic & Clinical Pharmacology & Toxicology·Javier MurielAna M Peiró
Sep 16, 2019·Biological Psychiatry·Lola WelschBrigitte Lina Kieffer
Oct 29, 2020·Internal Medicine Journal·Paul GlareMichael Nicholas
Nov 7, 2020·The Pharmacogenomics Journal·Christopher W MeadenCynthia D Santos
Aug 20, 2021·Neuroscience and Biobehavioral Reviews·Avinash VeerappaChittibabu Guda

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