Opsoclonus-myoclonus associated with celiac disease

Pediatric Neurology
Nicolas DeconinckBernard Dan

Abstract

Celiac disease may be associated with various neurologic manifestations, most commonly cerebellar ataxia. This report describes a 2-year-old male who presented with opsoclonus-myoclonus syndrome including action myoclonus, palpebral flutter, opsoclonus, and ataxia. Given the severity of ataxia, the child was unable to sit or walk independently. Brain magnetic resonance imaging was normal on two occasions (4-week interval). Oligoclonal bands were found in the cerebrospinal fluid. Blood and serum examinations were unremarkable, with no evidence of infectious seroconversion. However autoantibody testing indicated the presence of antigliadin antibodies of immunoglobulin A subtype, anti-endomysial antibodies, and anti-CV2 antibodies that were not, however, detected in the cerebrospinal fluid. Duodenal biopsy documented villous atrophy confirming the diagnosis of celiac disease. This case confirms that initial presentation of celiac disease may be restricted to neurologic features. We suggest that a search for evidence for celiac disease should be included in the evaluation of opsoclonus-myoclonus.

References

Jan 14, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·M T PellecchiaP Barone
Dec 21, 2000·Neuropathology and Applied Neurobiology·A J Wills
Aug 18, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H A HanagasiM Emre
Oct 9, 2002·Neurology·M T PellecchiaP Barone
Aug 26, 2003·Brain : a Journal of Neurology·Adrian J Wills, David J Unsworth
Jul 16, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Michael R PranzatelliSteven J Verhulst
Dec 3, 2004·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Elizabeth D TateSteven J Verhulst

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Citations

Feb 5, 2008·Medical & Biological Engineering & Computing·Laurent Loufrani, Daniel Henrion
Sep 4, 2007·Current Neurology and Neuroscience Reports·Matthew J ThurtellR John Leigh
Sep 13, 2008·The Cerebellum·Marios HadjivassiliouRichard A Grünewald
Aug 31, 2014·Current Neurology and Neuroscience Reports·José M Ferro, Sofia Oliveira
Dec 3, 2014·Neurologic Clinics·Shin C BehElliot M Frohman
Aug 15, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·R SalazarD Miller
Apr 1, 2015·The Cerebellum·Hiroshi MitomaNobuhiro Yuki
Mar 19, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Albert Garcia-Quintanilla, Domingo Miranzo-Navarro
Mar 27, 2015·Journal of Neurology·Wolfgang NachbauerSylvia Boesch
Aug 13, 2011·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·F J KirkhamC M Kipps
Nov 1, 2007·Expert Review of Clinical Immunology·Franz BlaesKlaus T Preissner
Jul 15, 2017·International Journal of Environmental Research and Public Health·Alessandra PacittoSusanna Esposito
May 19, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Khalil El-Chammas, Elaine Danner
Jan 12, 2007·Current Opinion in Neurology·Agnes Wong
Apr 23, 2008·International Ophthalmology Clinics·Marc J Dinkin, Joseph F Rizzo
Dec 23, 2017·CNS & Neurological Disorders Drug Targets·Marios Hadjivassiliou
May 2, 2018·Acta neurologica Belgica·Borislav RadicSibila Nankovic
Sep 21, 2017·Frontiers in Neuroscience·Manuela PennisiGiuseppe Lanza
Aug 12, 2018·Nutrients·Ana Vinagre-AragónMarios Hadjivassiliou
Feb 6, 2017·Pediatrics·Hilde KromAngelika Kindermann

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