Opsonic activity of blister fluid from burn patients.

Infection and Immunity
E A Deitch

Abstract

The combination of skin loss and immune depression after thermal injury predisposes burn patients to an increased risk of infection. Since the commonest site of infection in the burn patient is the burn wound itself, we elected to study the opsonic activity of locally produced blister fluid, from 18 thermally injured patients, for the two most common organisms colonizing the burn wound (Pseudomonas aeruginosa and Staphylococcus aureus). Blister fluid was as good an opsonin source for staphylococcus as normal serum. In contrast, the blister fluid did not support either the phagocytosis of the intracellular killing of P. aeruginosa. The poor opsonic activity of blister fluid for P. aeruginosa did not appear to be due to the presence of an inhibitory factor(s) since the addition of normal serum restored the opsonic activity of the blister fluid to normal. The concentrations of immunoglobulins and the complement components C3 and C4 in the blister fluid samples were less than half the level of those in normal serum. The opsonic activity of the blister fluid could not be restored to normal by the addition of either immunoglobulin or heat-inactivated serum (56 degrees C for 30 min). Thus, the opsonic factor(s) missing from the bliste...Continue Reading

References

Feb 1, 1979·The Journal of Clinical Investigation·C L Miller, C C Baker
Jun 1, 1977·The Journal of Surgical Research·C L Miller, D D Trunkey
Sep 1, 1979·The Journal of Trauma·C C BakerD D Trunkey
Nov 1, 1976·The Journal of Trauma·A B BjornsonH S Bjornson
Sep 1, 1976·The Journal of Trauma·J B Grogan
Jul 1, 1977·Annals of Surgery·A B BjornsonH S Bjornson
Jul 1, 1976·Annals of Surgery·F T Rapaport, R J Bachvaroff
Nov 1, 1975·American Journal of Surgery·T J Krizek, M C Robson
Mar 15, 1969·Lancet·G ArtursonJ Killander
Jan 1, 1974·The Journal of Trauma·H SakaiS E Ritzmann
Dec 1, 1970·Annals of Surgery·A M MunsterB A Pruitt
Jul 1, 1966·Archives of Surgery·J W Alexander, J A Moncrief
Dec 1, 1980·Annals of Surgery·A M MunsterP Keeling
Mar 1, 1982·The Journal of Trauma·E A DeitchJ C McDonald

❮ Previous
Next ❯

Citations

Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·E L Snyder, N L Luban
Mar 29, 2006·Journal of Burn Care & Research : Official Publication of the American Burn Association·Rachael L Sargent
Mar 7, 2012·Journal of Translational Medicine·Pamela S HairKenji M Cunnion

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
V M Avery, D L Gordon
Bulletin of the World Health Organization
G T KeuschH Smith
© 2021 Meta ULC. All rights reserved