PMID: 43289Dec 1, 1979

Opsonic activity of normal human cerebrospinal fluid for selected bacterial species

Infection and Immunity
R W TofteP G Quie

Abstract

The opsonic activity of normal human cerebrospinal fluid (CSF) has not been well defined. In this study, the opsonic activity of normal CSF for laboratory and blood culture isolates of Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Hemophilus influenzae type b, and Neisseria meningitidis was measured by a quantitative assay employing radiolabeled bacteria and polymorphonuclear leukocytes. All isolates of S. aureus, except the Wood 46 strain, were opsonized in undiluted CSF (>50% uptake by polymorphonuclear leukocytes.) There was heat-stable and heat-labile opsonic activity in CSF for S. aureus. Only one blood culture isolate of E. coli was moderately well opsonized in undiluted CSF (26% uptake). None of the remaining laboratory or clinical isolates were opsonized in undiluted CSF. The S. aureus isolates were more readily opsonized in dilute normal serum than were the other bacterial species, and complement appeared to be the heat-labile opsonin in serum. However, complement may not be the heat-labile opsonin in normal CSF for S. aureus. In contrast to serum, complement C3 was not visualized on the staphylococcal cell surface by immunofluorescence microscopy and chelation of CSF did not diminish opsonic activ...Continue Reading

References

Jul 8, 2011·Clinical Microbiology Reviews·Barry B Mook-KanamoriDiederik van de Beek

Related Concepts

Pathogenic Aspects
Neisseria meningitidis
Neutrophil Band Cells
Pathogenesis
Alkalescens-Dispar Group
Haemophilus influenzae
Meningitis, Haemophilus
Thylacodes aureus
Uptake
Immunofluorescence Microscopy

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