PMID: 697436Oct 1, 1978Paper

Opsonic alpha2 surface binding glycoprotein therapy during sepsis

Annals of Surgery
W A ScovillS R Powers

Abstract

A pronounced depletion of an opsonic protein for hepatic reticuloendothelial (RE) phagocytosis has been demonstrated in critically ill trauma patients. This opsonic alpha(2) surface binding (SB) glycoprotein has immunologic identity and a similar amino acid composition to cold insoluble globulin (CIg). Since CIg can be concentrated in cryoprecipitate, it was utilized as a readily available source of opsonic alpha(2)SB glycoprotein for replacement therapy after injury with documented hypoopsonemia. Six septic patients (2 multiple trauma, 2 thermal burn, and 2 intra-abdominal abscess) were studied to test whether cryoprecipitate infusion would restore this humoral component. Pre- and posttherapy opsonin levels were determined by bioassay and electroimmunoassay. In all patients, severe opsonin depletion was reversed following cryoprecipitate infusion. All patients had a rapid improvement in febrile state, normalization of leukocyte levels, and improvement in pulmonary function as evidenced by decreasing requirements for end expiratory pressure at lowered levels of inspired oxygen. One patient was studied more extensively and demonstrated an increase in cardiac output, limb blood flow, total body and limb oxygen delivery, total bod...Continue Reading

References

Jun 1, 1977·The Journal of Surgical Research·W A ScovillS R Powers
May 1, 1975·Annals of Surgery·L Walker, B Eiseman
Jul 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·N R Di Luzio, E S Lindsey
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