PMID: 3519829Jun 1, 1986Paper

Opsonic antibodies evoked by hybrid peptide copies of types 5 and 24 streptococcal M proteins synthesized in tandem

The Journal of Experimental Medicine
E H BeacheyJ M Seyer

Abstract

The protective immunogenicity of a hybrid peptide containing tandem copies of types 5 and 24 epitopes was investigated. Carboxy-terminal peptides of the cyanogen bromide-derived fragment 7 (CB7) of type 24 M protein were chemically synthesized, and then extended to include the first 20 residues of the amino-terminus of type 5 M protein. When emulsified in CFA and injected into rabbits without conjugation to a carrier, each of the synthetic hybrid peptides, designated S-M5(1-20)-S-CB7(23-35)C and S-M5(1-20)-S-CB(19-34), evoked opsonic antibodies against both types 5 and 24 streptococci without raising heart tissue-crossreactive immunity. These results suggest that tandem hybrid peptides may provide a new approach to the development of multivalent vaccines, not only to different serotypes of group A streptococci but perhaps also to a variety of other infectious agents.

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Citations

Apr 1, 1988·Vaccine·E H BeacheyS Sargent
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W Kraus, E H Beachey
Jul 25, 2000·Clinical Microbiology Reviews·M W Cunningham
Mar 1, 1988·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·O KühnemundW Köhler
Jun 24, 2009·PLoS Neglected Tropical Diseases·Andrew C SteerJonathan R Carapetis
Apr 4, 2014·Clinical Microbiology Reviews·Mark J WalkerVictor Nizet
Mar 1, 2008·Proteomics. Clinical Applications·Jason N ColeMark J Walker
May 15, 2010·Scandinavian Journal of Infectious Diseases·Trond BruunSteinar Skrede
May 4, 2017·Journal of Medical Microbiology·Aniela WozniakPatricia García
May 22, 2019·Microbiology Spectrum·Vincent A Fischetti
Jul 1, 1989·Clinical Microbiology Reviews·V A Fischetti
Aug 1, 1989·Infection and Immunity·W KrausE H Beachey
May 1, 1988·Infection and Immunity·R TerttiA Toivanen

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