Optic disc cupping characteristics of normal pressure hydrocephalus patients with normal-tension glaucoma

Scientific Reports
Nozomi IgarashiMakoto Aihara

Abstract

We examined the potential association of idiopathic normal pressure hydrocephalus (iNPH) with the generation of normal-tension glaucoma (NTG), to explore possible relationships between intracranial pressure (ICP) and the presence of glaucoma, and to compare disc morphology of NTG patients with or without iNPH. We investigated 20 iNPH patients, examined the prevalence of glaucoma, and compared the optic discs of NTG patients with iNPH (n = 11) and age-matched NTG patients without iNPH (n = 16). All data were collected prior to the treatment of iNPH, to eliminate the possibility that the treatment may have contributed to the progression of NTG. The diagnoses of NTG were made using visual field data, intraocular pressure measurements, fundoscopy, and optical coherence tomography (OCT). Using OCT, the optic nerve disc depth was also measured. The ICP was higher in the iNPH with NTG compared to iNPH without NTG (p = 0.0425), and the cupping depths of the discs of NTG patients with iNPH were significantly shallower compared with those of NTG patients without iNPH (p = 0.0097). Based on the difference in cupping depth, NTG patients with iNPH may have a different morphology from typical glaucoma patients, which could in turn reflect a ...Continue Reading

References

Apr 1, 1996·Ophthalmology·M T Nicolela, S M Drance
Jun 13, 1998·American Journal of Ophthalmology·D C BroadwayF S Mikelberg
Mar 2, 1999·The Journal of Physiology·D H Triyoso, T A Good
Jun 10, 2000·Current Opinion in Ophthalmology·G Tomita
Jan 3, 2001·Microscopy Research and Technique·J E Preston
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R Bech-AzeddineM Juhler
Mar 27, 2002·European Neurology·A U BayerC Erb
Apr 28, 2004·Brain : a Journal of Neurology·Gerald D Silverberg
May 26, 2004·Lancet·Robert N Weinreb, Peng Tee Khaw
Sep 8, 2004·Ophthalmology·Aiko IwaseUNKNOWN Tajimi Study Group, Japan Glaucoma Society
Nov 25, 2004·Neuroscience·P D BrownI D Millar
Jun 21, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·H StephensenC Wikkelsö
Feb 21, 2006·The British Journal of Ophthalmology·H A Quigley, A T Broman
Mar 28, 2006·Journal of the Neurological Sciences·Hiroki TamuraHiromu K Mishima
Dec 7, 2007·Clinical Neurology and Neurosurgery·Peter WostynPeter Paul De Deyn
May 3, 2008·Ophthalmology·John P BerdahlDouglas H Johnson
Aug 23, 2008·Investigative Ophthalmology & Visual Science·John P BerdahlR Rand Allingham
Nov 7, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sohan Singh Hayreh
Mar 13, 2009·The New England Journal of Medicine·Young H KwonWallace L M Alward
Mar 20, 2009·Journal of Glaucoma·Ta C Chang, Kuldev Singh
Dec 9, 2009·Ophthalmology·Ruojin RenNingli Wang
Jul 14, 2010·Journal of Glaucoma·Peter WostynPeter Paul De Deyn
Aug 12, 2010·Japanese Journal of Ophthalmology·Toru NakazawaKohji Nishida
Jul 20, 2011·Medical Hypotheses·Peter WostynPeter Paul De Deyn
Feb 22, 2012·Journal of Alzheimer's Disease : JAD·Jean-Marie SerotPierre Jouanny
Aug 15, 2015·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Timothy J McCulleyW Jordan Piluek
Mar 11, 2016·Acta Radiologica Open·Véronique PromelleOlivier Balédent

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Citations

Jun 18, 2020·International Journal of Molecular Sciences·Wioletta Rozpędek-KamińskaIreneusz Majsterek
Nov 18, 2020·Investigative Ophthalmology & Visual Science·Henrik Holvin JacobsenPer Kristian Eide

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