Optic Disc Image Subtraction as an Aid to Detect Glaucoma Progression

Translational Vision Science & Technology
Navid AminiJoseph Caprioli

Abstract

To present a digital image subtraction technique to alert clinicians to signs of glaucomatous optic disc progression. Ninety-two glaucomatous eyes (65 patients) were included. Thirty-three eyes were identified as progressive and 59 as stable based on comparison of baseline and follow-up stereoscopic disc photographs by three masked glaucoma specialists. The disc images were aligned and converted to gray scale and underwent histogram matching to enhance contrast and account for illumination differences. The difference in image intensity between baseline and follow-up images was shown as a colormap superimposed on the grayscale follow-up image. A graded scale (1, no progression, to 5, definitive progression) was used by three masked glaucoma experts to score progression probability on the colormap images. Sensitivity, specificity, and accuracy of the classification were computed. Weighted κ statistics summarized agreement of categorical gradings. Median time interval between two visits was 4.4 years (range: 1.0-16.8). Clinicians detected glaucoma deterioration in 25 to 27 of the progressive group and 8 to 10 of stable eyes based on subtraction maps. Sensitivities/specificities of the clinicians were 0.76 to 0.82 and 0.86 to 0.89,...Continue Reading

Software Mentioned

matched
GPA
MATLAB
i2k Align Retina
Guided Progression Analysis ( GPA )

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