Optic nerve involvement in childhood onset systemic lupus erythematosus: Three cases and a review of the literature

Lupus
D SuriS Singh

Abstract

The ocular system can be affected in systemic lupus erythematosus (SLE) in one third of patients. However, optic nerve involvement is relatively uncommon, but is more so in pediatric SLE patients, where it can occur in 1% of cases. We report three children with SLE who presented with optic nerve involvement. Two children had optic neuritis, with optic neuritis being the first manifestation in one child. The third child had ischaemic optic neuropathy secondary to antiphospholipid syndrome. A careful work up for SLE should be performed in every child with optic nerve disease. Prompt diagnosis and early treatment results in a better prognosis.

References

May 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·I V AllenR K Shillington
Feb 1, 1988·Archives of Ophthalmology·D A JabsS L Fine
Apr 1, 1986·Archives of Ophthalmology·D A JabsM B Stevens
Jul 1, 1974·Archives of Neurology·E R HackettR M Paddison
May 13, 1999·The American Journal of Medicine·G Galindo-RodríguezC Lavalle
Nov 29, 2001·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·R M SiatkowskiE M Sklar
Aug 8, 2007·Rheumatology·R R SivarajCaroline Gordon
Feb 2, 2008·Arthritis and Rheumatism·Hermine I BrunnerEarl D Silverman

❮ Previous
Next ❯

Citations

Dec 16, 2017·Clinical and Experimental Medicine·Rosanna Dammacco

❮ Previous
Next ❯

Methods Mentioned

BETA
ESR
biopsy

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.