PMID: 2494299Apr 1, 1989Paper

Optic nerve regeneration in adult fish and apolipoprotein A-I

Journal of Neurochemistry
A HarelM Schwartz

Abstract

Fish optic nerves, unlike mammalian optic nerves, are endowed with a high capacity to regenerate. Injury to fish optic nerves causes pronounced changes in the composition of pulse-labeled substances derived from the surrounding non-neuronal cells. The most prominent of these injury-induced changes is in a 28-kilodalton (kDa) polypeptide whose level increases after injury, as revealed by one-dimensional gel electrophoresis and autoradiography. The present study identified as apolipoprotein A-I (apo-A-I) a polypeptide of 28 kDa in media conditioned by regenerating fish optic nerves. The level of this polypeptide increased after injury by approximately 35%. Apo-A-I was isolated by gel-permeation chromatography from delipidated high-density lipoproteins (HDL) that had been obtained from carp plasma by sequential ultracentrifugation. Further identification of the purified protein as apo-A-I was based on its molecular mass (28 kDa) as determined by gel electrophoresis, amino acid composition, and microheterogeneity studies. The isolated protein was further analyzed by immunoblots of two-dimensional gels and was found to contain six isoforms. Western blot analysis using antibodies directed against the isolated plasma protein showed th...Continue Reading

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Citations

Dec 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·M I VeraM Krauskopf
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A J Dowding, J Scholes
Aug 29, 2009·Journal of Biochemistry·Tomo NishidaShinji Yokoyama
Oct 3, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·M Schwartz
Dec 1, 1992·Experimental Neurology·F R ThormodssonB Grafstein
Sep 19, 2002·Journal of Atherosclerosis and Thrombosis·Hidehiko FujiiTsuyoshi Takami
Jun 6, 2007·Journal of Lipid Research·Jin-Ichi ItoShinji Yokoyama
Apr 8, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Michal Schwartz
Feb 11, 1999·Journal of Neuroscience Research·T González-Hernández, A Rustioni
Jun 23, 1998·Annals of Clinical Biochemistry·H SongK Nakashima
May 8, 1994·The Journal of Comparative Neurology·T SivronM Schwartz

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