Optic Nerve Sheath Tethering in Adduction Occurs in Esotropia and Hypertropia, But Not in Exotropia

Investigative Ophthalmology & Visual Science
Soh Youn SuhJoseph L Demer

Abstract

Repetitive strain to the optic nerve (ON) due to tethering in adduction has been recently proposed as an intraocular pressure-independent mechanism of optic neuropathy in primary open-angle glaucoma. Since strabismus may alter adduction, we investigated whether gaze-related ON straightening and associated globe translation differ in horizontal and vertical strabismus. High-resolution orbital magnetic resonance imaging was obtained in 2-mm thick quasi-coronal planes using surface coils in 25 subjects (49 orbits) with esotropia (ET, 19 ± 3.6Δ SEM), 11 (15 orbits) with exotropia (XT, 33.7 ± 7.3Δ), 7 (12 orbits) with hypertropia (HT, 14.6 ± 3.2Δ), and 31 normal controls (62 orbits) in target-controlled central gaze, and in maximum attainable abduction and adduction. Area centroids were used to determine ON path sinuosity and globe positions. Adduction angles achieved in ET (30.6° ± 0.9°) and HT (27.2° ± 2.3°) did not significantly differ from normal (28.3° ± 0.7°), but significantly less adduction was achieved in XT (19.0° ± 2.5°, P = 0.005). ON sheath tethering in adduction occurred in ET and HT similarly to normal, but did not in XT. The globe translated significantly less than normal, nasally in adduction in XT and temporally in...Continue Reading

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Oct 19, 2016·American Journal of Ophthalmology·Melinda Y ChangJoseph L Demer
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Apr 7, 2017·Investigative Ophthalmology & Visual Science·Xiaofei WangMichaël J A Girard
Aug 9, 2017·Journal of Biomechanical Engineering·Andrew ShinJoseph L Demer
Aug 23, 2017·Investigative Ophthalmology & Visual Science·Joseph L DemerJoseph Caprioli

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Citations

Aug 20, 2019·BMC Ophthalmology·Kunte ShangJost B Jonas
Oct 17, 2019·Investigative Ophthalmology & Visual Science·Jessica Y ChenJoseph L Demer
Jan 5, 2021·Investigative Ophthalmology & Visual Science·Somaye JafariJoseph L Demer
Apr 21, 2021·Biomechanics and Modeling in Mechanobiology·Joseph ParkJoseph L Demer

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