Optic nerve swelling and gadolinium contrast enhancement on magnetic resonance imaging in the subacute stage of Leber's hereditary optic neuropathy: a case report

Rinshō shinkeigaku = Clinical neurology
Misako FurukiHidehiro Mizusawa

Abstract

We report the case of a 50-year-old man with subacute onset of bilateral visual field loss and visual acuity loss. His visual acuity was 0.07 OD/0.09 OS and Goldmann perimetry showed central scotomas. The optic fundi were normal bilaterally. Magnetic resonance imaging (MRI) showed hyperintensity in the right optic nerve on T(2) weighted imaging and swelling of the optic chiasm with slight enhancement of the bilateral optic nerves and the optic chiasm on gadolinium-enhanced imaging. Since sensory disturbance in the left hand and leg was noted in addition to the visual problem, multiple sclerosis (MS) was suspected initially. The patient was treated with intravenous methylprednisolone (1,000 mg/day), plasma exchange therapy, and immunosuppressant therapy. However, his visual disturbance did not improve. He had a history of deafness and family history of visual disturbance, because of which we performed an analysis of mitochondrial DNA. G11778A point mutation was found, and a diagnosis of Leber's hereditary optic neuropathy (LHON) was made. Although gadolinium contrast enhancement and swelling of the optic nerve are rare, this case shows that these findings are not in conflict with LHON. The present case also suggests that mitocho...Continue Reading

References

Sep 25, 2001·Journal of Neurology·N AhrensJ Haas
Mar 19, 2002·Journal of Medical Genetics·P Yu-Wai-ManP F Chinnery
Mar 5, 2003·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Michael S VaphiadesRoger E Turbin
Oct 6, 2009·Journal of the Neurological Sciences·Jacqueline Palace
May 13, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Cédric LamirelChristophe Verny

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Citations

Jan 5, 2018·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Christelle BlancCatherine Vignal-Clermont
Feb 12, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Shilei CuiXiaojun Zhang

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