Optic neuritis associated with etanercept therapy for juvenile arthritis

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
T TauberY Morad

Abstract

We sought to describe cases of optic neuritis associated with etanercept therapy. A retrospective chart review was undertaken on all patients that developed uveitis or optic neuritis associated with etanercept therapy between January 2003 and January 2005 in 2 medical centers: Assaf Harofeh Medical Center, and Kaplan Medical Center, Israel. Four patients (3 girls, 1 boy) treated with etanercept for juvenile idiopathic arthritis (JIA) are presented. The 3 girls had oligoarticular-onset JRA. The boy had HLA-B27-positive juvenile spondyloarthropathy and bilateral uveitis. After a mean follow-up of 10 months (range, 2.5-18 months) all 4 patients had reduced visual acuity due to optic neuritis, which was accompanied by vitreitis in 2 eyes. In 3 patients, the discontinuation of etanercept, together with steroid treatment, resulted in resolution of the inflammation. The fourth patient elected to continue etanercept treatment and experienced no further deterioration in visual acuity. Optic neuritis is a potentially sight-threatening complication of etanercept therapy. Patients with JRA who are candidates for therapy should be examined by an ophthalmologist before starting treatment and then regularly thereafter. Ophthalmologists and rh...Continue Reading

References

Jan 1, 1992·The Clinical Investigator·B HeiligW Hunstein
May 1, 1992·British Journal of Rheumatology·F M BrennanM Feldmann
Aug 1, 1990·Documenta Ophthalmologica. Advances in Ophthalmology·E Adachi-UsamiY Yamamoto
Jul 1, 1994·Electroencephalography and Clinical Neurophysiology·B StigsbyK el-Ramahi
Dec 14, 1999·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·T FukaiJ Mizuguchi
Apr 17, 2001·The Annals of Pharmacotherapy·C J JohnsonK M Murray
Feb 13, 2002·Arthritis and Rheumatism·Justine R Smith, James T Rosenbaum
Apr 12, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Roy FleischmannAndres Quiceno
Apr 11, 2003·Arthritis and Rheumatism·Pierre QuartierAnne-Marie Prieur
Jun 19, 2003·The British Journal of Ophthalmology·A R Reddy, O C Backhouse
Aug 2, 2003·Journal of the American Academy of Dermatology·Ben Goffe, Jennifer Clay Cather
May 30, 2006·Arthritis and Rheumatism·Daniel J LovellUNKNOWN Pediatric Rheumatology Collaborative Study Group

❮ Previous
Next ❯

Citations

May 15, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Manuel Diaz-LlopisFrancisco J Romero
Mar 5, 2011·Pediatric Dermatology·Uxua FloristanRaul De Lucas
Apr 26, 2007·Annals of the Rheumatic Diseases·Ismail SimsekAyhan Dinc
Feb 27, 2007·The British Journal of Ophthalmology·Ahmad M Mansour
Aug 5, 2011·Journal of Neuroinflammation·Andrew J Steelman, Jianrong Li
Apr 17, 2013·Clinical Rheumatology·Rosario PelusoMatteo Nicola Dario Di Minno
Mar 6, 2008·Seminars in Immunopathology·Steven YehRobert B Nussenblatt
Jan 14, 2016·Journal of Crohn's & Colitis·Benjamin AlexandreUNKNOWN ECCO CONFER investigators
Nov 5, 2013·Rheumatic Diseases Clinics of North America·Andreas ReiffSeza Özen
Dec 8, 2015·The British Journal of Radiology·Kanimozhi VendhanMargaret A Hall-Craggs
Dec 14, 2011·Seminars in Arthritis and Rheumatism·María Cruz Fernández-EsparteroUNKNOWN BIOBADASER Study Group
May 18, 2011·Annals of Tropical Paediatrics·R Abd-RashidI Shatriah
Jan 25, 2012·The Journal of Dermatological Treatment·Satveer K MahilCatherine H Smith
Dec 3, 2014·Revista brasileira de reumatologia·Daniela M R LourençoClovis A Silva
Mar 10, 2017·Clinical Neuropharmacology·Marta de Frutos-LezaunJavier Olascoaga
Sep 27, 2007·Clinical & Experimental Ophthalmology·Vicky ChangLynn K Gordon
Jan 9, 2008·Current Opinion in Neurology·Gordon T Plant
May 15, 2018·Journal of the American Association of Nurse Practitioners·Mary Jane S Hanson
May 12, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Tanya Kowalski, Heather G Mack
Sep 1, 2007·Expert Review of Clinical Immunology·Steven YehGrace A Levy-Clarke
Sep 27, 2014·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Jessica R Chang, Neil R Miller
Apr 28, 2020·Journal of Ophthalmic Inflammation and Infection·Fernanda Nicolela Susanna, Carlos Pavesio
Sep 3, 2010·Ocular Immunology and Inflammation·Sing Your LiDebra A Goldstein
Nov 5, 2010·Rheumatology·Taunton R SouthwoodUNKNOWN British Society for Adolescent and Paediatric Rheumatology Biologics and New Drugs Register
Oct 27, 2006·Current Opinion in Ophthalmology
May 17, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Jérémie SellamChristophe Richez
Oct 21, 2010·Autoimmunity Reviews·Alessandra Goncalves CommodaroLuiz Vicente Rizzo
Nov 4, 2021·American Journal of Clinical Dermatology·Mahsaw MotlaghBobeck S Modjtahedi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here