Optic neuropathy and meningioma: a diagnostic trap

Journal français d'ophtalmologie
M BouyonJ de Seze

Abstract

Meningiomas are benign primary meningeal tumors. Their diagnosis may be incidental or in response to a work-up for neurological or ophthalmological symptoms. The clinical course of five patients with ophthalmological symptoms leading to the diagnosis of meningioma is described. The case reports consist of five women (48 to 54 years old - mean 52 years at the onset of symptoms), all suffering from a progressive unilateral decrease in visual acuity with a normal initial fundus examination and ipsilateral visual field changes. Ancillary testing, in particular MRI and CT-scans, had to be repeated to make the diagnosis of meningioma, which was delayed from 18 months to 4 years. The clinical presentation of these five cases was that of a retrobulbar optic neuropathy, which biased the work-up towards an inflammatory disease of the central nervous system such as multiple sclerosis. However, the atypical character of the neuropathy, which did not respond to intravenous steroids, caused the diagnosis to be questioned and radiological examinations repeated. The iso-intense appearance of meningiomas on T1 MR imaging and only slightly hyperintense appearance on T2 may result in a diagnostic delay if the exam is not performed and interpreted...Continue Reading

References

Nov 1, 1992·Survey of Ophthalmology·J J Dutton
Jan 1, 1991·Surgical and Radiologic Anatomy : SRA·J TamrazE A Cabanis
Oct 1, 1990·AJR. American Journal of Roentgenology·L E HendrixL F Czervionke
Aug 1, 1980·The British Journal of Ophthalmology·J E WrightS Liaricos
Dec 1, 1996·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·A G LeeE B Butler
Jun 11, 1998·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·D F KlinkJ Williams
Feb 23, 1999·Radiologic Clinics of North America·M F MafeeS Dorodi
Feb 24, 2001·International Ophthalmology Clinics·T T ShenJ F Rizzo
Apr 13, 2002·Neurosurgery·James K LiuDeborah L Benzil
Oct 19, 2002·The British Journal of Ophthalmology·S PitzE Zrenner
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Samir NarayanJames A Hayman
Oct 3, 2003·Ophthalmology·Peerooz SaeedLeo Koornneef
Sep 1, 2005·Current Neurology and Neuroscience Reports·Mark L Moster
Jul 21, 2006·Ophthalmic Plastic and Reconstructive Surgery·Roger E TurbinJohn S Kennerdell

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Citations

Jan 6, 2016·Proceedings. Mathematical, Physical, and Engineering Sciences·C AmraN Rolland
Jul 25, 2013·Neuro-ophthalmology·Jérôme de Seze

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