Optical characteristics of the canine prostate at 665 nm sensitized with tin etiopurpurin dichloride: need for real-time monitoring of photodynamic therapy

The Journal of Urology
Jerzy JankunSteven H Selman

Abstract

Photodynamic therapy (PDT) is an emerging, minimally invasive therapy for prostate cancer that depends on the sequestration of a photosensitizing drug within targeted tissue. The photosensitizer is subsequently activated by light of a specific wavelength, resulting in destruction of the targeted tissue. Successful treatment requires knowledge of the optical properties of the target tissue, a critical element for therapy. Adult canines were injected with tin etiopurpurin dichloride (1.0 mg/kg) as a liposome emulsion vehicle in saline 24 hours prior to light treatment. Laser light was delivered to the prostate via a 400 microm optical fiber fitted with a 2.0 cm cylindrical diffuser and optical properties of the prostate were measured. In this study we determined the attenuation coefficient and critical fluence in the canine prostate. Our studies shown that the attenuation coefficient is not uniform but higher at the base (average for all animals 2.59 to 2.79 cm-1) than in the mid section or apex of the prostate (1.71 to 1.90 cm-1). Significant differences among dogs (0.11 to 12.70 cm-1) were found. In some cases we observed a fluctuation of the attenuation coefficient during treatment. We also established experimentally the minim...Continue Reading

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Sep 11, 2004·Physics in Medicine and Biology·Lothar LilgeJerzy Jankun

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Citations

Mar 9, 2007·Journal of Biomedical Optics·Tomas SvenssonKatarina Svanberg
Nov 8, 2011·Lasers in Surgery and Medicine·Caroline M MooreStephen G Bown
May 18, 2005·Journal of Photochemistry and Photobiology. B, Biology·Robert A WeersinkBrian C Wilson
Jul 23, 2008·Technology in Cancer Research & Treatment·Zheng HuangYang K Chen
May 18, 2005·Technology in Cancer Research & Treatment·Z Huang
Sep 4, 2009·Journal of Biomedical Optics·Mark A MackanosChristopher H Contag
Mar 23, 2006·Physics in Medicine and Biology·Natalie Pomerleau-Dalcourt, Lothar Lilge
Dec 20, 2005·Expert Review of Medical Devices·Nathaniel M Fried
Aug 10, 2010·Chemical Society Reviews·Manivannan EthirajanRavindra K Pandey

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