Abstract
The imaging characteristics of drug-eluting in-stent restenosis (ISR) at different times varied; however, the mechanism had not yet been elucidated.To analyze the imaging characteristics of drug-eluting ISR at different time points by optical coherence tomography (OCT) and investigate the cause of the stent treatment failure.A total of 70 patients with drug-eluting ISR undergoing OCT were enrolled (intimal hyperplasia ≥50% of stent area) and implanted with drug-eluting stents. According to stent implantation time, the patients were divided into 2 groups: early in-stent restenosis group (E-ISR group) (group A, n = 35, stent age ≤12 months) and late in-stent restenosis group (L-ISR group) (group B, n = 35, stent age ≥24 months). A qualitative analysis of the restenosis tissue included the nature of restenosis tissue (homogeneous and heterogeneous), neoatherosclerosis, thin-cap fibroatheroma (TCFA), and microvessels.The ratio of ≥75% cross-sectional area stenosis between the L-ISR and E-ISR groups was (60.00% vs 34.28%, P < .05). The heterogeneous intima, neoatherosclerosis, TCFA, and microvessels were more prevalent in the L-ISR group as compared to the E-ISR group (71.43% vs 45.71%, P < .05; 48.57% vs 22.86%, P < .05; 25.71% vs ...Continue Reading
References
Sep 25, 2002·Circulation·Hiroshi YabushitaGuillermo J Tearney
Dec 7, 2005·Circulation·E RegarP W Serruys
Aug 9, 2007·Circulation·Masaki AwataSeiki Nagata
Sep 18, 2007·Lancet·Christoph StettlerPeter Jüni
Jan 25, 2008·The New England Journal of Medicine·Oscar C MarroquinKevin E Kip
Jul 22, 2009·American Heart Journal·Nieves GonzaloEvelyn Regar
Mar 10, 2010·American Heart Journal·Kyung Woo ParkHyo-Soo Kim
Jun 12, 2010·The American Journal of Cardiology·Hironori KitabataTakashi Akasaka
Mar 8, 2011·Journal of the American College of Cardiology·Gaku NakazawaRenu Virmani
May 3, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Antonio CurcioCiro Indolfi
Jun 8, 2011·Circulation·Soo-Jin KangSeung-Jung Park
Oct 1, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Dariusz DudekPatrick W Serruys
Apr 18, 2012·European Heart Journal·Salvatore BrugalettaPatrick W Serruys
Jun 26, 2012·The American Journal of Cardiology·Taishi YonetsuIk-Kyung Jang
Oct 31, 2012·International Journal of Cardiology·Nobuaki SuzukiTakaaki Isshiki
Jan 24, 2013·European Heart Journal Cardiovascular Imaging·Hirohiko AndoToyoaki Murohara
Jul 31, 2013·The American Journal of Cardiology·Rocco VergalloIk-Kyung Jang
Sep 26, 2013·Circulation. Cardiovascular Interventions·Ziad A AliAnnapoorna S Kini
Jan 5, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Seung-Yul LeeMyeong-Ki Hong
Sep 17, 2014·Internal Medicine·Michitaka AmiokaUNKNOWN HERO (Hiroshima Heart Study Group) Investigators
Mar 31, 2015·JACC. Cardiovascular Interventions·Andrea MangiameliCorrado Tamburino
May 15, 2015·Circulation. Cardiovascular Interventions·Antonios KaranasosEvelyn Regar
May 23, 2015·JACC. Cardiovascular Interventions·Yasunori UedaKazuhisa Kodama
Aug 22, 2015·JACC. Cardiovascular Interventions·Teresa BastanteFernando Alfonso
Jan 14, 2016·European Heart Journal·Geraud SouteyrandUNKNOWN PESTO Investigators
Feb 20, 2016·Journal of the American College of Cardiology·Patrick W SerruysYoshinobu Onuma
Feb 27, 2016·Journal of the American College of Cardiology·Serban PuricelTommaso Gori
Jul 13, 2016·International Journal of Cardiology·Gianluca CaiazzoCarlo Di Mario
Oct 28, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Rocco VergalloIk-Kyung Jang
Nov 4, 2016·Lancet·Patrick W SerruysYoshinobu Onuma
Dec 19, 2016·Journal of the American College of Cardiology·Annapoorna S KiniSamin Sharma
Mar 30, 2017·The American Journal of Cardiology·Hideo AmanoTakanori Ikeda
Apr 13, 2017·The New England Journal of Medicine·Joanna J WykrzykowskaUNKNOWN AIDA Investigators
May 15, 2018·Kardiologia polska·Sandeep BasavarajaiahRichard Watkin