Optical coherence tomography angiography changes in radial peripapillary capillaries in Leber hereditary optic neuropathy

American Journal of Ophthalmology Case Reports
Mitsuhiro MatsuzakiYasuo Kurimoto

Abstract

To present a report of longitudinal changes in radial peripapillary capillaries (RPC) and changes in retinal full thickness (RFT) and peripapillary retinal nerve fiber layer (RNFL) in a patient with Leber hereditary optic neuropathy (LHON). A 42-year-old man presented with acute- and presymptomatic-stage LHON in the left (OS) and right (OD) eyes, respectively, at the initial visit. Onset of LHON in the OD was observed 2 months after the initial visit. Once the temporal RNFL started to decrease in thickness, the areas of temporal RPC defects and RFT thinning gradually increased, indicating that these factors might be correlated. Optical coherence tomography angiography showed LHON from the presymptomatic stage. The results indicate that temporal RPC defects and RFT thinning start to spread once the pseudoedema begins to resolve.

Citations

May 24, 2018·Clinical & Experimental Ophthalmology·Nicole BalducciPiero Barboni
Mar 19, 2019·Intractable & Rare Diseases Research·Samuel AsanadAlfredo A Sadun
Oct 20, 2018·Current Neurology and Neuroscience Reports·Adam Wylęgała
Jun 25, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Ling WangWen Qin

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