Optical Coherence Tomography Angiography Compared With Optical Coherence Tomography Macular Measurements for Detection of Glaucoma

JAMA Ophthalmology
Kelvin H WanChristopher Kai-shun Leung

Abstract

Whether optical coherence tomography angiography (OCT-A) outperforms OCT to detect glaucoma remains inconclusive. To compare (1) the diagnostic performance for detection of glaucoma and (2) the structure-function association between inner macular vessel density and inner macular thickness. This cross-sectional study included 115 patients with glaucoma and 35 healthy individuals for measurements of retinal thickness and retinal vessel density, segmented between the anterior boundary of internal limiting membrane and the posterior boundary of the inner plexiform layer, over the 3 × 3-mm2 macula using swept-source OCT. All participants were Chinese. Visual sensitivity corresponding to the 3 × 3-mm2 macular region was expressed in unlogged 1/lambert for investigation of the structure-function associations. Diagnostic performance was evaluated with area under the receiver operating characteristic curves (AUCs). The study was conducted between January 12, 2016, and December 12, 2016. Area under the receiver operating characteristic curve and R2 analysis. Of the 115 patients with glaucoma, 42 (36.5%) were women (mean [SD] age, 53.5 [13.4] years); of the 35 individuals with healthy eyes, 25 (71.4%) were women (age, 60.6 [5.9] years). I...Continue Reading

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Citations

Dec 24, 2018·Current Opinion in Ophthalmology·Karine D BojikianJoanne C Wen
Apr 18, 2019·Investigative Ophthalmology & Visual Science·Corey A SmithBalwantray C Chauhan
Jun 4, 2019·Seminars in Ophthalmology·Astrid C Werner, Lucy Q Shen
Jul 17, 2019·Experimental Dermatology·Martin Metz
Feb 14, 2020·Journal of Glaucoma·Harsha L RaoRobert N Weinreb
Apr 15, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Alexandra M CoffeyPaul A Constable
Jun 21, 2020·Acta Ophthalmologica·Songhomitra Panda-JonasJost B Jonas
Oct 19, 2019·Japanese Journal of Ophthalmology·Nozomu UchidaGoji Tomita
Nov 7, 2020·Scientific Reports·Timothy P H LinClement C Tham
Jun 30, 2021·The British Journal of Ophthalmology·Qi Sheng YouDavid Huang
Aug 3, 2021·Ophthalmology. Glaucoma·Huiyuan HouRobert N Weinreb
Jul 10, 2021·Annual Review of Vision Science·Alexi GeevargheseJoel S Schuman
Aug 24, 2020·American Journal of Ophthalmology·Kazunori HirasawaBalwantray C Chauhan
Nov 26, 2021·Frontiers in Neuroscience·Jing Hong LooRachel S Chong
Dec 21, 2021·Translational Vision Science & Technology·Alessandro RabioloFrancesco Bandello
Jan 19, 2022·Translational Vision Science & Technology·Weijing ChengXiulan Zhang

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