Optical coherence tomography angiography for screening of hydroxychloroquine-induced retinal alterations

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Mehmet BulutHasan Fatih Çay

Abstract

The purpose of the study was to evaluate the retinal and choroidal changes via optical coherence tomography angiography (OCTA) in patients who received hydroxychloroquine (HCQ). Sixty eyes of 60 female patients who received HCQ were included in the study. Patients were categorized into two groups as high-risk (≥ 5 years) and low-risk (< 5 years) in terms of HCQ-induced retinal toxicity. Spectral domain-OCT, OCTA, and visual field tests were performed. Retinal thickness, vascular density, flow rates, choroidal thickness (CT), and visual field parameters were compared between the groups, and the correlation between total HCQ cumulative dose, duration of use, and these parameters was assessed. Compared to low-risk group, patients in the high-risk group had vascular density loss (p < 0.05). In this group, foveal avascular zone (FAZ) was found to be wider (p < 0.05). Retinal and choroidal flow rates were found to be decreased markedly in the high-risk group (p < 0.05). CT was found to be thinner in the high-risk group (p < 0.05). HCQ cumulative dose and duration of use had a negative significant correlation with all vascular density, flow rate, CT parameters, and positive significant correlation with FAZ parameters (p < 0.05). In vi...Continue Reading

References

Feb 5, 2011·Ophthalmology·Michael F MarmorUNKNOWN American Academy of Ophthalmology
Mar 11, 2015·Journal of Biochemical and Molecular Toxicology·Nicoline M KorthagenWillem A Dik
Jul 24, 2015·JAMA Ophthalmology·Liang LiuDavid Huang
Mar 20, 2016·Ophthalmology·Michael F MarmorUNKNOWN American Academy of Ophthalmology
May 14, 2016·Expert Review of Medical Devices·Rupesh AgrawalAniruddha Agarwal
Feb 27, 2017·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Paulo Ricardo Chaves De OliveiraDavid Robert Chow
Mar 11, 2017·Eye·I H YusufS M Downes
Jun 6, 2017·Survey of Ophthalmology·Kumar SambhavKakarla V Chalam
Sep 12, 2017·American Journal of Ophthalmology·Seong Joon AhnByung Ro Lee
Oct 2, 2017·American Journal of Ophthalmology·Seong Joon AhnByung Ro Lee

❮ Previous
Next ❯

Citations

Nov 9, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A RickmannG Szurman
Dec 11, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Viktoria C BrücherMaged Alnawaiseh
Sep 4, 2020·Vestnik oftalmologii·M V Budzinskaya, M H Durzhinskaya
Jun 14, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Nataša MihailovicViktoria C Brücher
Dec 21, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·N MihailovicM Alnawaiseh
Dec 20, 2019·International Ophthalmology Clinics·Mohammad Dahrouj, Lucy Young
Aug 29, 2020·International Ophthalmology·Hatice Nur TarakciogluUlviye Yigit
Mar 25, 2021·Cutaneous and Ocular Toxicology·Naciye KabataşCem Özişler
Jul 28, 2021·European Journal of Ophthalmology·Pierluigi IaconoMaurizio Battaglia Parodi
Jan 28, 2022·European Journal of Ophthalmology·Lidia Remolí SarguesEnrique Cervera Taulet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.