Optical coherence tomography-angiography for monitoring neovascularisations in macular telangiectasia type 2.

The British Journal of Ophthalmology
Simone TzaridisFrank G Holz

Abstract

To evaluate the utility of optical coherence tomography-angiography (OCT-A) for monitoring activity, progression and response to therapy of neovascularisations (NVs) secondary to macular telangiectasia type 2 (MacTel). In a retrospective analysis, eyes with NVs secondary to MacTel were reviewed over a period of ≥8 months. Examinations at monthly intervals included visual acuity testing, dilated funduscopy, spectral domain-OCT and OCT-A. Eyes were treated with intravitreal VEGF (vascular endothelial growth factor)-inhibitors following a pro-re-nata (PRN) regime, and treatment decisions were based on morphological signs of activity as determined by B-scan OCT and funduscopy. Signs of neovascular activity were defined as an increase in retinal thickness, presence/increase of intraretinal/subretinal fluid and haemorrhages. A total of 19 eyes from 17 patients were analysed. Patients were evaluated over a mean period of 13.4 months (range: 8.9 to 24.2). OCT-A permitted the monitoring of both treatment effects (regression) and progression (growth) of NVs, but not neovascular activity. The growth of neovascular vessels was detectable in OCT-A before signs of activity occurred on OCT. NVs showed a progressive growth over time despite PR...Continue Reading

References

Sep 1, 1996·Archives of Ophthalmology·D ParkR N Johnson
Mar 7, 2002·Archives of Ophthalmology·Nicholas E EngelbrechtMary Lou Lewis
Jun 10, 2004·Retina·Frederick H DavidorfRobert B Chambers
Apr 12, 2006·Archives of Ophthalmology·Lawrence A YannuzziBarbara Blodi
Dec 1, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Rodrigo JorgeIngrid U Scott
Feb 3, 2007·Ophthalmology·David S BoyerUNKNOWN MARINA Study Group
Mar 9, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Subrata MandalSatpal Garg
Jul 31, 2007·American Journal of Ophthalmology·Otacílio Oliveira MaiaBeatriz Sayuri Takahashi
Oct 24, 2007·Indian Journal of Ophthalmology·Mahesh P ShanmugamNitin S Shetty
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Dec 12, 2012·Progress in Retinal and Eye Research·Peter Charbel IssaHendrik P N Scholl
Aug 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Dae Yu KimJohn S Werner
Oct 3, 2015·Retina·Richard F SpaideNadia K Waheed
Oct 27, 2015·Developments in Ophthalmology·Peter Charbel IssaFrank G Holz
Oct 27, 2015·Retina·Richard F SpaideNadia K Waheed
Sep 25, 2017·Current Eye Research·P MalamosIlias Georgalas
Jul 22, 2018·American Journal of Ophthalmology·Maximilian W M WintergerstRobert P Finger
Aug 11, 2018·Retina·Richard F SpaidePeter M Maloca
Feb 28, 2019·The British Journal of Ophthalmology·Simone TzaridisPhilipp Herrmann
Aug 16, 2019·Investigative Ophthalmology & Visual Science·Simone TzaridisPhilipp Herrmann

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Citations

Jan 9, 2021·The British Journal of Ophthalmology·Stefanie MuellerDaniel Pauleikhoff
Mar 25, 2021·Retina·Prithvi RamtohulPierre Gascon
Jun 26, 2021·The British Journal of Ophthalmology·Kristina HessSimone Tzaridis
Aug 15, 2021·Eye·Daniel PauleikhoffEmily Y Chew

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