Optical Coherence Tomography Angiography in Intermediate Uveitis

American Journal of Ophthalmology
Maximilian W M WintergerstRobert P Finger

Abstract

To investigate the involvement of the retinal and choriocapillaris microvasculature in intermediate uveitis on optical coherence tomography angiography (OCT-A). Case-control study. Patients and age-matched controls were imaged with swept-source OCT-A. Using ImageJ, superficial and deep retinal vasculature were semi-automatically analyzed for vessel (VD) and skeleton density (SD), vessel diameter index (VDI), and fractal dimension (FD). Choriocapillaris layer was automatically graded for mean signal intensity, signal intensity standard deviation, kurtosis of signal intensity distribution, and flow signal voids. Twenty-nine intermediate uveitis eyes and 30 control eyes were included. Both superficial and deep retinal layers showed significant reduction in all OCT-A parameters (eg, superficial retinal layer: 0.31 vs 0.40 VD, 5.6e-8 vs 6.4e-8 SD, 5.4e6 vs 6.1e6 VDI, and 1.78 vs 1.79 FD, respectively, all P < .05). At the choriocapillaris layer a greater heterogeneity of perfusion with a shift toward a higher proportion of large confluent flow signal voids was present. Also in the absence of macular edema OCT-A parameters were reduced when compared with healthy controls (all parameters except for VDI in the superficial retinal layer...Continue Reading

Citations

Feb 6, 2019·Clinical & Experimental Ophthalmology·Alessandro InvernizziGiovanni Staurenghi
Apr 15, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Alexandra M CoffeyPaul A Constable
May 30, 2019·Journal of Ophthalmic Inflammation and Infection·Vita L S DingerkusMatthias Becker
Aug 21, 2020·Ocular Immunology and Inflammation·Sana KhochtaliMoncef Khairallah
Jul 3, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Qian XuYi Qu
Nov 19, 2019·Acta Ophthalmologica·Maximilian Wilhelm Maria Wintergerst, Robert P Finger
Oct 28, 2019·Ocular Immunology and Inflammation·Sana KhochtaliMoncef Khairallah
Jun 10, 2020·The British Journal of Ophthalmology·Simone TzaridisFrank G Holz
Aug 16, 2019·Investigative Ophthalmology & Visual Science·Simone TzaridisPhilipp Herrmann
Jan 8, 2021·Survey of Ophthalmology·Nazanin EbrahimiadibC Stephen Foster
Mar 13, 2021·Current Opinion in Ophthalmology·Akshay S Thomas, Phoebe Lin
Aug 11, 2020·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Philipp L MüllerFrank G Holz
Dec 31, 2021·Translational Vision Science & Technology·Wijak KongwattananonShilpa Kodati

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