Optical coherence tomography angiography of the foveal avascular zone in diabetic retinopathy

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Florentina J FreibergStephan Michels

Abstract

To analyze foveal avascular zone (FAZ) dimensions and symmetry in patients with diabetic retinopathy (DR) compared to healthy controls using optical coherence tomography angiography (OCT angiography). OCT angiography was performed via an Avanti® RTVue 100 XR OCT system (Optovue, Inc., Fremont, CA, USA) in patients with diabetes mellitus (DM) and healthy adults. A frame centered on the fovea was used for FAZ measurements. The borders of the superficial vascular layer were defined as 3 μm below the internal limiting membrane (ILM) and 15 μm below the inner plexiform layer (IPL), and for the deep vascular layer as15 μm and 70 μm below the IPL, respectively. Angles of maximum FAZ diameter were measured in all eyes by two graders. In healthy eyes (N = 25), the FAZ surrounding vascular arcades were intact, showing a vertical or horizontal oval symmetrical formation with a maximum diameter usually on the horizontal or vertical axis. Diabetic eyes (N = 29) presented with disintegrity of the vascular arcades, resulting in an enlarged FAZ. In the superficial layer, the mean horizontal FAZ diameter was significantly larger in the DR group (753 μm ±272 μm) than in the control group (573 μm ±177 μm, p = 0.029). The difference was even more ...Continue Reading

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Citations

Mar 10, 2016·Indian Journal of Ophthalmology·Colin Siang Hui TanSrinivas R Sadda
Apr 27, 2016·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Jessica I W Morgan
May 14, 2016·American Journal of Ophthalmology·Fabio ScarinciAmani A Fawzi
Sep 16, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Eduardo A NovaisJay S Duker
Nov 15, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Haiyan WangHui Cao
Dec 16, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Colin S TanSriniVas R Sadda
Jul 2, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Joel HanhartYaakov Rozenman
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Mar 21, 2018·European Journal of Ophthalmology·Salomon Y CohenSarah Mrejen
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Dec 27, 2019·Ophthalmic Surgery, Lasers & Imaging Retina·Mirriam MikhailNetan Choudhry
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Aug 22, 2020·European Journal of Ophthalmology·Hooshang FaghihiMohammad Riazi Esfahani
Oct 22, 2016·Current Diabetes Reports·Jessica Lee, Richard Rosen

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

SPSS
ImageJ

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