Optical Coherence Tomography Angiography of Retinal Microvascular Changes Overlying Choroidal Nodules in Neurofibromatosis Type 1

Case Reports in Ophthalmology
Catherine CassimanJulie Jacob

Abstract

To report 3 cases of neurofibromatosis type 1 (NF1) with choroidal nodules associated with retinal microvascular changes imaged with optical coherence tomography angiography (OCTA). Small case series in 3 NF1 patients. OCTA examinations were performed by a trained examiner (J.J.) after pupillary dilation. A standard scan, centered over the macula measuring 6 × 6 mm and 3 × 3 mm was obtained according to the findings on standard color photography. Additional scans were obtained in the zones with microvascular abnormalities. The segmentation provided by the machine software was used. Corkscrew retinal vessels were observed in association with "placoid"-type choroidal nodules as shown by near-infrared reflectance imaging. In all cases, multiple lesions were found. They were second- or third-order tortuous vessels originating from the superior or inferior temporal veins. OCTA demonstrated that the tortuous venules were located in the superficial capillary plexus, and no abnormalities were found in the deep capillary plexus. Corkscrew retinal vessels are part of a spectrum of retinal microvascular alterations seen in association, sometimes overlying choroidal nodules in patients with NF1 and are visualized in the superficial capilla...Continue Reading

References

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Citations

Feb 2, 2019·The British Journal of Ophthalmology·Antonietta MoramarcoSandra Giustini
Sep 25, 2020·Current Opinion in Ophthalmology·Stephanie B EngelhardMrinali P Gupta
Nov 23, 2019·Indian Journal of Ophthalmology·Adrian J BattistonCarol L Shields
Oct 4, 2020·Current Opinion in Ophthalmology·Stephanie B EngelhardMrinali P Gupta
Mar 25, 2021·Orphanet Journal of Rare Diseases·Antonietta MoramarcoSandra Giustini
Mar 24, 2021·Seminars in Ophthalmology·Alessandro de PaulaGianluca Scuderi

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Methods Mentioned

BETA
imaging technique

Software Mentioned

OCTA

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