Optical Coherence Tomography for the Detection of Remote Optic Neuritis in Multiple Sclerosis

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Lucy T XuPeter K Kaiser

Abstract

Evidence of remote optic neuritis is often used to support a diagnosis of multiple sclerosis (MS). Optical coherence tomography (OCT) can provide qualitative and quantitative data on the retina, where the effects of optic neuritis can be seen. Our aim was to determine whether there is a quantitative difference in retinal structures in eyes with optic neuritis compared with those without, and which measures were best able to discriminate eyes with a history of optic neuritis from nonoptic neuritis eyes in MS patients. We performed a prospective cohort study of 30 MS-optic neuritis patients, 22 MS-nonoptic neuritis patients, and 24 healthy participants. Patients underwent visual acuity testing and OCT imaging. Retinal measurements were compared across groups. OCT measurements and visual acuities were analyzed for their ability to discriminate between optic neuritis and nonoptic neuritis eyes. Optic neuritis eyes exhibited a thinner peripapillary retinal nerve fiber layer, papillomacular bundle, and ganglion cell + inner plexiform layer thicknesses compared to MS eyes without optic neuritis and healthy controls. Papillomacular bundle thickness was the best model to discriminate between eyes with optic neuritis and nonoptic neuriti...Continue Reading

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Citations

Apr 13, 2017·The Cerebellum·Fernando Spina TensiniHélio A G Teive
Jun 26, 2018·Asia-Pacific Journal of Ophthalmology·Noel C Y Chan, Carmen K M Chan
May 16, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Jeffrey LambeRobert A Bermel
Dec 14, 2019·Therapeutic Advances in Chronic Disease·Timothy E YapM Francesca Cordeiro
Jun 2, 2017·Journal of Neurology·Josefine BritzeJette Lautrup Frederiksen

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