Optical coherence tomography predictors of retinal pigment epithelial tear following intravitreal bevacizumab injection

Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye
Iris MorozAmir Alhalel

Abstract

To evaluate the ability of optical coherence tomography (OCT) to predict the risk of retinal pigment epithelium (RPE) tear in patients with choroidal neovascular membrane associated with pigment epithelium detachment treated with bevacizumab. Retrospective observational case series of 24 consecutive patients treated with bevacizumab. All patients had sequential OCT scans performed before treatment and during follow-up. Six patients developed an RPE tear. Eighteen patients served as the non-tear group. Wavy RPE indentations or small interruptions and breaks in the elevated RPE were evident in all six patients who developed an RPE tear, whereas only two of the remaining 18 patients had such findings (P < .001). Indentations or minute interruptions and breaks in the RPE layer seen on OCT were correlated with increased risk of developing an RPE tear in patients with pigment epithelium detachment following treatment with bevacizumab.

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Citations

May 12, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Akio OishiYasuo Kurimoto
Dec 31, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Małgorzata Figurska
May 26, 2011·Seminars in Ophthalmology·Andrew J Barkmeier, Petros E Carvounis
Mar 10, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Shane R DurkinJagjit Gilhotra
Dec 7, 2010·Optometry : Journal of the American Optometric Association·Brenda Yeh, Steven Ferrucci
Aug 3, 2021·Journal of Ophthalmology·Cristian MetrangoloClaudio Azzolini

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