Optical coherence tomography reveals light-dependent retinal responses in Alzheimer's disease.

NeuroImage
David BissigJacqueline T Bernard

Abstract

Spectral-domain optical coherence tomography (SD-OCT) is an accessible clinical tool for measuring structural changes to the retina, and increasingly as a biomarker for brain-predominant neurodegenerative diseases like Alzheimer's. Information about retinal function can also be extracted from OCT images, but is under-studied, with literature examples often employing challenging protocols or requiring specialized hardware. The first goal of this study was to verify that functional retinal imaging was feasible with a commercially-available SD-OCT device and a clinically practical protocol. Inspired by methods from other functional imaging modalities, we acquired images while repeatedly cycling lights on and off, and spatially normalized retinas to facilitate intra- and inter-individual analyses. In eight healthy young adults, light-dependent increases in reflectivity were easily demonstrated at photoreceptor inner and outer segments, changing by ~7% in bright light and ~3% in dim light. Bright light elicited a subtle (~2%) but consistent light-dependent decrease in reflectivity through much of the rest of the retina, including the avascular outer nuclear layer (ONL). We speculated that some of these changes are influenced by glia...Continue Reading

References

Sep 20, 2000·The Anatomical Record·A HarmanR Hoskins
Nov 19, 2003·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Andreas BringmannAndreas Reichenbach
Mar 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·K BizhevaW Drexler
Jul 15, 2006·Progress in Retinal and Eye Research·Andreas BringmannAndreas Reichenbach
Apr 24, 2007·Brain : a Journal of Neurology·Toshiyuki TakahashiYasuto Itoyama
May 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kristian FranzeJochen Guck
Jan 1, 2009·American Journal of Alzheimer's Disease and Other Dementias·Ludovico MinatiGiorgio Giaccone
Jun 16, 2009·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Jessica M NeuvilleAnthony J Adams
Sep 19, 2009·Japanese Journal of Ophthalmology·Alexandre R TumlinsonWolfgang Drexler
Sep 30, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jérôme BadautAndre Obenaus
Nov 13, 2010·Investigative Ophthalmology & Visual Science·Brandon J LujanJoseph Carroll
May 24, 2011·Progress in Retinal and Eye Research·F Behar-CohenD Attia
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Dec 6, 2012·Investigative Ophthalmology & Visual Science·Billy R HammondJames G Elliott
Mar 22, 2013·Neurology·Elias S SotirchosPeter A Calabresi
May 2, 2013·Investigative Ophthalmology & Visual Science·Michael D AbràmoffEdwin M Stone
Aug 29, 2013·Investigative Ophthalmology & Visual Science·Wataru SuzukiManabu Tanifuji
Oct 19, 2013·Science·Lulu XieMaiken Nedergaard
Nov 5, 2013·Biochimica Et Biophysica Acta·Kevin L ScheyYing Qi
Jan 9, 2014·Investigative Ophthalmology & Visual Science·Yuchun TsaiShaomei Wang
Jul 30, 2014·Biomedical Optics Express·Min ChenAaron Carass
Nov 12, 2014·International Journal of Molecular Medicine·Chaoqi LiuDing Xu
Sep 8, 2015·Progress in Retinal and Eye Research·Bruce A BerkowitzRobin Roberts
Jul 15, 2016·Investigative Ophthalmology & Visual Science·Yichao LiHaohua Qian
Jan 6, 2017·Neurology. Neuroimmunology and Neuroinflammation·Paola ValentinoAntonio Bertolotto
Mar 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Pengfei ZhangEdward N Pugh
Apr 11, 2017·Translational Vision Science & Technology·Melissa A WilkJoseph Carroll
Aug 18, 2017·JCI Insight·Yosef KoronyoMaya Koronyo-Hamaoui
Sep 13, 2017·Investigative Ophthalmology & Visual Science·Chen D LuJames G Fujimoto
Oct 27, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Kevin G BurfeindJeffrey J Iliff
Jan 4, 2018·Biomedical Optics Express·Andreas WartakChristoph K Hitzenberger
Feb 27, 2018·Translational Psychiatry·Stephanie R Rainey-SmithUNKNOWN AIBL Research Group
Apr 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Ehsan Shokri-KojoriNora D Volkow
Apr 15, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackUNKNOWN Contributors

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Citations

Jul 16, 2021·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Lei ChenZhenkun Lei

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