Optical control of L-type Ca2+ channels using a diltiazem photoswitch.

Nature Chemical Biology
Timm FehrentzDirk Trauner

Abstract

L-type Ca2+ channels (LTCCs) play a crucial role in excitation-contraction coupling and release of hormones from secretory cells. They are targets of antihypertensive and antiarrhythmic drugs such as diltiazem. Here, we present a photoswitchable diltiazem, FHU-779, which can be used to reversibly block endogenous LTCCs by light. FHU-779 is as potent as diltiazem and can be used to place pancreatic β-cell function and cardiac activity under optical control.

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Citations

Jan 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Barbara PatriziMario Siciliani de Cumis
Mar 5, 2020·Chemistry : a European Journal·Manzoor AhmedPinaki Talukdar
Jul 11, 2019·Nature Reviews. Neuroscience·Pierre PaolettiAlexandre Mourot
Jul 17, 2020·Chemical Society Reviews·Yin FangBozhi Tian
Jul 19, 2018·Nature Chemical Biology·Marc Vendrell
Mar 23, 2020·The Journal of Sexual Medicine·Alejandro Sevilleja-OrtizJavier Angulo
Nov 7, 2020·Journal of Biomechanical Engineering·Peiyuan KangZhenpeng Qin
Apr 25, 2020·Journal of the American Chemical Society·Xingye YangMinyong Li
Aug 31, 2019·Journal of the American Chemical Society·Natalie L MutterGiovanni Maglia
Sep 2, 2021·ACS Chemical Neuroscience·Maxim V NikolaevDenis B Tikhonov
Oct 1, 2021·Chemical Society Reviews·Jana VolarićBen L Feringa

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Methods Mentioned

BETA
X-ray
FRET
chip

Software Mentioned

Zen
HEKA
MC Rack
Igor Pro
ImageJ ( Fiji )
Fitmaster
Igor Pro Tools
Excel
MOPAC
Patchmaster

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