Optical control of neuronal firing via photoinduced electron transfer in donor-acceptor conjugates

Chemical Science
Yuta TakanoHiroshi Imahori

Abstract

A series of porphyrin-fullerene linked molecules has been synthesized to evaluate the effects of substituents and molecular structures on their charge-separation yield and the lifetime of a final charge-separated state in various hydrophilic environments. The selected high-performance molecule effectively achieved depolarization in a plasma cell membrane by visible light as well as two-photon excitation using a near-infrared light laser. Moreover, it was revealed that the depolarization can trigger neuronal firing in rat hippocampal neurons, demonstrating the potential and versatility for controlling cell functions using light.

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Citations

Dec 15, 2019·Chemistry : a European Journal·Devika SasikumarVasudevanpillai Biju
Sep 18, 2020·Chemical Communications : Chem Comm·Yuta TakanoHiroshi Imahori
Feb 1, 2017·Science Advances·Claudia TortiglioneGuglielmo Lanzani
Sep 14, 2018·Frontiers in Bioengineering and Biotechnology·Caterina BossioMaria Rosa Antognazza

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Methods Mentioned

BETA
Dynamic light scattering
AFM

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