Optical Electrophysiology in the Developing Heart

Journal of Cardiovascular Development and Disease
Kandace ThomasMichael Bressan

Abstract

The heart is the first organ system to form in the embryo. Over the course of development, cardiomyocytes with differing morphogenetic, molecular, and physiological characteristics are specified and differentiate and integrate with one another to assemble a coordinated electromechanical pumping system that can function independently of any external stimulus. As congenital malformation of the heart presents the leading class of birth defects seen in humans, the molecular genetics of heart development have garnered much attention over the last half century. However, understanding how genetic perturbations manifest at the level of the individual cell function remains challenging to investigate. Some of the barriers that have limited our capacity to construct high-resolution, comprehensive models of cardiac physiological maturation are rapidly being removed by advancements in the reagents and instrumentation available for high-speed live imaging. In this review, we briefly introduce the history of imaging approaches for assessing cardiac development, describe some of the reagents and tools required to perform live imaging in the developing heart, and discuss how the combination of modern imaging modalities and physiological probes ...Continue Reading

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Citations

Aug 24, 2018·Journal of Cardiovascular Development and Disease·Robert H AndersonBjarke Jensen
May 8, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Robert E Poelmann, Adriana C Gittenberger-de Groot
Mar 22, 2020·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Marina NechaevaIgor Kubasov

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Methods Mentioned

BETA
imaging techniques
chemical treatment
chip
transgenic
biosensors
biosensor
transfection

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