Optical fiber-coupled ocular spectrometer for measurement of drug concentration in the anterior eye--applications in pharmaceuticals research

IEEE Transactions on Bio-medical Engineering
J MillerD Uttamchandani

Abstract

This paper describes in detail a novel optoelectronic system designed to measure drug absorption in the anterior segment of the eye following topical application of drug formulations. This minimally invasive measurement technique offers both a method for determining drug concentration in human eyes, and demonstrates an alternative to current testing processes in model animals, which require paracentesis of the anterior chamber of the eye. The optoelectronic technique can be used with formulations, which possess appropriate spectral characteristics, namely unique absorption or fluorescence spectra. Preliminary experiments using our measurement system have been performed in rabbit and man, where we have been successful in achieving the direct measurement of topically applied brimonidine, an alpha-2 agonist used in the treatment of glaucoma. This demonstrates the feasibility of performing real-time, in vivo testing of ophthalmic drug formulations in the eye of human test subjects. We further demonstrate the novel application of the optoelectronic system for detection of topically applied UV-absorbing compounds in rabbit cadaver eyes, with a view to evaluating potential ocular sunscreen formulations. In summary, this method can be ...Continue Reading

References

Mar 1, 1975·Physics in Medicine and Biology·M W Charles, N Brown
Jan 1, 1991·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C KesslerG Kleintges
Nov 1, 1986·The British Journal of Ophthalmology·J CaprioliR P Wilson
Jan 1, 1972·Vision Research·A Hughes
Jan 1, 1994·Documenta Ophthalmologica. Advances in Ophthalmology·W AmbachA Daxer
Jul 1, 1994·The CLAO Journal : Official Publication of the Contact Lens Association of Ophthalmologists, Inc·P MichalosP S Hersh
Apr 1, 1996·Current Eye Research·J W McLaren, R F Brubaker
Jan 1, 1996·Cornea·C S BouchardJ M Holmes
Jul 28, 2001·Diabetes Technology & Therapeutics·B D CameronG L Coté
Jan 31, 2002·Journal of Biomedical Optics·Joe MillerDeepak Uttamchandani
May 2, 2002·Clinical and Experimental Immunology·M A ThielK A Williams
Mar 29, 2003·Journal of Cataract and Refractive Surgery·Ilgaz Sagdic YalvacSunay Duman
Apr 11, 2003·Current Opinion in Infectious Diseases·Julius Schachter, Chandler R Dawson
Nov 18, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T SengokuS Mutoh
Apr 27, 2004·Experimental Eye Research·Clive G Wilson
Oct 19, 2004·American Journal of Ophthalmology·Jonas J KuehneMichael J Giese
Apr 13, 2005·Archives of Ophthalmology·Tin AungPaul J Foster
Aug 23, 2005·The British Journal of Ophthalmology·J MillerD Uttamchandani
Jan 27, 2006·Current Opinion in Ophthalmology
May 6, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yanyan KoenigClaus Cursiefen

❮ Previous
Next ❯

Citations

Jan 31, 2002·Journal of Biomedical Optics·Joe MillerDeepak Uttamchandani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
W K KekD Uttamchandani
Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
Matthias GruebT Schlote
Klinische Monatsblätter für Augenheilkunde
M GrübM Rohrbach
© 2021 Meta ULC. All rights reserved