PMID: 8603215Mar 1, 1996Paper

Optical immunoassay for rapid detection of group A beta-hemolytic streptococci. Should culture be replaced?

Archives of Pediatrics & Adolescent Medicine
T A SchlagerJ O Hendley

Abstract

To evaluate an optical immunoassay rapid antigen test to detect group A beta-hemolytic streptococci directly from throat swab specimens. Criterion standard with "blinded" comparison. Double-swab pharyngeal samples were obtained; one swab was cultured and the other was used for the rapid antigen test. Microbiology laboratory in a primary care center at a university teaching hospital. Two hundred sixty-two outpatients with pharyngitis. The results of the optical immunoassay rapid antigen test were compared with results of standard aerobic culture. Sixty-two (24%) of 262 samples were culture-positive; 48 of these 62 were positive by the optical immunoassay rapid test (sensitivity, 77%). Of the 200 culture-negative samples, seven (4%) were positive by the rapid test (specificity, 96%). The optical immunoassay performed well, but like other rapid tests, is not sensitive enough to replace standard culture for detection of group A beta-hemolytic streptococci.

Citations

Jul 20, 2004·Clinical Microbiology Reviews·Michael A Gerber, Stanford T Shulman
Jan 12, 2016·Analytical Chemistry·Dillon SchiffYaakov R Tischler
Aug 19, 2006·Brazilian Journal of Otorhinolaryngology·Bernardo Cunha Araujo FilhoFlávio Akira Sakae
Apr 2, 1999·Emergency Medicine Clinics of North America·M H StewartR K Cydulka
Feb 15, 2001·The New England Journal of Medicine·A L Bisno
Jul 5, 2016·The Cochrane Database of Systematic Reviews·Jérémie F CohenMartin Chalumeau
Jun 12, 1998·Pediatric Annals·M A Gerber
Oct 3, 2006·Expert Review of Molecular Diagnostics·Alexander K C LeungH Dele Davies
Jun 28, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alan L BisnoUNKNOWN Infectious Diseases Society of America
Jan 5, 2018·Infection & chemotherapy·Young Kyung YoonShin Woo Kim
Mar 22, 2019·Pediatric Investigation·Amin J BarakatDavid Nelson
Mar 29, 2001·Annals of Emergency Medicine·G E RooseveltS T Shulman
Nov 18, 1998·Journal of Clinical Microbiology·C A NeedhamK H Webb

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