PMID: 1207784Dec 17, 1975Paper

Optical isomers of verapamil on canine heart. Prevention of ventricular fibrillation induced by coronary artery occlusion, impaired atrioventricular conductance and negative inotropic and chronotropic effects

Naunyn-Schmiedeberg's Archives of Pharmacology
A J Kaumann, J R Serur

Abstract

Effects of optical isomers of verapamil on the canine heart were measured with a pressure catheter in the left ventricle and with the electrocardiogram. 1. Both isomers of verapamil caused impaired atrioventricular conduction. slowed the rate of the sinus pacemaker and depressed the contractile state of the myocardium. (-)-Verapamil was consistently more potent than (+)-verapamil in producing these effects. (-)/(+) potency ratios of 10 and 3 were estimated for atrioventricular blockade and for the negative chronotropic effect, respectively. 2. Negative inotropic effects of 0.06-2.0 mg/kg of (+)-verapamil were determined on hearts paced at constant rate. A similar dose-response relationship could not be established with (-)-verapamil because at concentration higher than 0.06 mg/kg the hearts did not follow the supraventricular driving stimulus. With doses of (-)- and (+)-verapamil which produced the same slowing of the sinus pacemaker rate in spontaneously beating hearts, (-)-verapamil caused greater negative inotropic effects than (+)-verapamil. 3. The following doses of isomers of verapamil reduced the incidence of ventricular fibrillation induced by coronary artery ligation: 0.2 mg/kg (-)-verapamil (P less than 0.001), 0.6 mg...Continue Reading

References

Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·H TritthartA Fleckenstein
Jan 1, 1972·Pflügers Archiv : European journal of physiology·M KohlhardtA Fleckenstein
Mar 11, 1972·British Medical Journal·L SchamrothC Garrett
Mar 1, 1970·The Journal of Physiology·G W Beeler, H Reuter
Jan 1, 1969·Pflügers Archiv : European journal of physiology·R KaufmannH Tritthart

❮ Previous
Next ❯

Citations

Aug 10, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Stephan HoffmannPeter Wiedemann
Jan 14, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·A J Kaumann, O D Uchitel
Sep 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·F Chollet-DebordP Duchene-Marullaz
Mar 1, 1985·British Journal of Clinical Pharmacology·L M WingK J Lillywhite
Apr 1, 1984·British Journal of Clinical Pharmacology·M EichelbaumB Vogelgesang
Jul 11, 2006·European Journal of Clinical Pharmacology·Dagmar BusseKari T Kivistö
Jan 1, 1988·Neurochemical Research·G E Gibson, V Mykytyn
Mar 14, 2002·Biopharmaceutics & Drug Disposition·Suneel GuptaLeon Aarons
Jan 1, 1982·Annals of the New York Academy of Sciences·D P Zipes, R F Gilmour
Jan 1, 1985·Molecular Aspects of Medicine·J H BottingM J Walker
Feb 18, 1982·The American Journal of Cardiology·W T ClusinJ S Schroeder

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.