PMID: 9449133Feb 4, 1998Paper

Optical isometric force transducer for measurement of rat skeletal muscle contraction in the NMR spectrometer

NMR in Biomedicine
K Yamane, F Mitsumori

Abstract

In order to measure force of contraction of the rat gastrocnemius muscle in the NMR spectrometer with a simultaneous observation of 31P NMR spectra, an optical force transducer was constructed using gratings and optical fibers. Muscle contraction was accurately recorded in the spectrometer without interfering with NMR measurements. The half height width of the phosphocreatine (PCr) peak in the presence or absence of the transducer was 5 Hz. Decrease in PCr and increase in inorganic phosphate (Pi) in the muscle were successfully followed during monitoring of the force developed during exercise. The change in the PCr:(PCr + Pi) ratio correlated well with the time-force integral from the optical force transducer. In general, there was no interference with the 31P NMR spectrum when the transducer was attached to rat leg, so this optical force transducer should prove valuable for studying muscle physiology in the NMR spectrometer.

References

Feb 1, 1976·Journal of Applied Physiology·P G Canaday, F S Fay
Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·S Y KunoF Mitsumori
Sep 1, 1992·The American Journal of Physiology·M J KushmerickT R Brown
Nov 1, 1992·Journal of the Neurological Sciences·J F DunnG K Radda
Aug 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S LareauR Deslauriers
Mar 1, 1988·The American Journal of Physiology·R A ChallissG K Radda
Apr 1, 1988·The American Journal of Physiology·R A Meyer
Nov 1, 1993·Journal of Applied Physiology·A R CogganP M Robitaille

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Citations

Feb 9, 2008·Muscle & Nerve·Benoit GiannesiniDavid Bendahan
Sep 30, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Benoit GiannesiniDavid Bendahan
Jun 24, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Benoît GiannesiniDavid Bendahan

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