Optical Microangiography: A Label Free 3D Imaging Technology to Visualize and Quantify Blood Circulations within Tissue Beds in vivo.

IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society
Ruikang K Wang

Abstract

Optical microangiography (OMAG) is a recently developed volumetric imaging technique that is capable of producing 3D images of dynamic blood perfusion within microcirculatory tissue beds in vivo. The imaging contrast of OMAG image is based on the intrinsic optical scattering signals backscattered by the moving blood cells in patent blood vessels, thus it is a label free imaging technique. In this paper, I will first discuss its recent developments that use a constant modulation frequency introduced in the spectral interferograms to achieve the blood perfusion imaging. I will then introduce its latest development that utilizes the inherent blood flow to modulate the spectral interferograms to realize the blood perfusion imaging. Finally, examples of using OMAG to delineate the dynamic blood perfusion, down to capillary level resolution, within living tissues are given, including cortical blood perfusion in the brain of small animals and blood flow within human retina and choroids.

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Citations

Oct 12, 2010·Journal of Neuroscience Methods·Yali Jia, Ruikang K Wang
Oct 8, 2014·Ophthalmic Surgery, Lasers & Imaging Retina·Mariana R ThorellPhilip J Rosenfeld
Feb 26, 2016·Scientific Reports·Qinqin ZhangRuikang K Wang
Mar 9, 2017·Biomedical Optics Express·Chieh-Li Chen, Ruikang K Wang
Jan 23, 2018·Lasers in Surgery and Medicine·Anthony J DeeganRuikang K Wang
Nov 18, 2016·The British Journal of Ophthalmology·Alexander D LinCecilia S Lee
Apr 28, 2018·Journal of Biomedical Optics·Jonas OlsenGregor B Jemec
Aug 31, 2016·International Ophthalmology Clinics·Muhammad HassanDiana V Do
Sep 29, 2019·Ocular Immunology and Inflammation·Massimo AccorintiMariacristina Parravano
Sep 30, 2017·Retina·Eleonora CorbelliGiuseppe Querques
Aug 18, 2016·The British Journal of Ophthalmology·Lea QuerquesFrancesco Bandello
Aug 26, 2014·Journal of Biomedical Optics·Xin YinRuikang K Wang
Dec 27, 2016·Biomedical Optics Express·Maciej SzkulmowskiMaciej Wojtkowski
Jul 30, 2016·Optics Letters·M PellizzariM Atlan
Aug 16, 2019·Investigative Ophthalmology & Visual Science·Simone TzaridisPhilipp Herrmann
Apr 16, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wenri ZhangNabil J Alkayed
May 21, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Fanny M ElahiAmir H Kashani
Jun 18, 2021·Journal of Pain Research·Zehao Wu, Yun Wang
Jun 15, 2021·Experimental Biology and Medicine·Arash DadkhahShuliang Jiao

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