Abstract
A key challenge of central nervous system tumor surgery is to discriminate between brain regions infiltrated by tumor cells and surrounding healthy tissue. Although monitoring of autofluorescence could potentially be an efficient way to provide reliable information for these regions, we found little information on this subject, and thus we conducted studies of brain tissue optical properties. This particular study focuses on the different optical quantitative responses of human central nervous system tumors and their corresponding controls. Measurements were performed on different fixed human tumoral and healthy brain samples. Four groups of central nervous system tumors (glioblastoma, diffuse glioma, meningioma and metastasis) were discriminated from healthy brain and meninx control tissues. A threshold value was found for the scattering and absorption coefficient between tumoral and healthy groups. Emission Spectra of healthy tissue had a significant higher intensity than tumoral groups. The redox and optical index ratio were thenn calculated and these also showed significant discrimination. Two fluorescent molecules, NADH and porphyrins, showed distinct lifetim values among the different groups of samples. This study defines...Continue Reading
References
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J R BarrioG Weber
Jul 18, 2002·Physics in Medicine and Biology·A N YaroslavskyH J Schwarzmaier
Aug 2, 2003·Medical & Biological Engineering & Computing·J SwartlingS Andersson-Engels
Nov 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Melissa C SkalaNirmala Ramanujam
Mar 8, 2008·Applied Optics·F BevilacquaC Depeursinge
Apr 2, 2010·Chemical Reviews·Mikhail Y Berezin, Samuel Achilefu
Apr 15, 2010·Optics Express·Riccardo CicchiFrancesco S Pavone
Nov 9, 2010·NeuroImage·Pramod V ButteLaura Marcu
Jan 1, 1996·Journal of Biomedical Optics·A TaddeucciG Zaccanti
May 15, 2013·Physics in Medicine and Biology·Steven L Jacques
May 24, 2014·Photodiagnosis and Photodynamic Therapy·Garry PapayanMichael Galagudza
Jan 13, 2015·European Journal of Histochemistry : EJH·A C Croce, G Bottiroli
Apr 25, 2015·Biomedical Optics Express·D Abi HaidarR Siebert
Feb 13, 2016·Journal of Biophotonics·Marc ZanelloDarine Abi-Haidar
Oct 8, 2016·Journal of Biophotonics·Scott PalmerGhulam Nabi
Nov 15, 2016·Optics Letters·A IbrahimD Abi Haidar
Feb 6, 2017·Scientific Reports·Marc ZanelloDarine Abi Haidar
Feb 6, 2017·Neuro-Chirurgie·J Pallud, E Dezamis
Citations
May 29, 2018·Journal of Biophotonics·Benjamin PradèreDarine Abi Haidar
Sep 12, 2018·Journal of Biophotonics·Hussein MehidineDarine Abi Haidar
May 7, 2019·Operative Neurosurgery·Christoph BettagDorothee Mielke
Jul 26, 2018·Scientific Reports·Mira SibaiDarine Abi Haidar
Jul 6, 2019·Journal of Biophotonics·Mira SibaiDarine Abi Haidar
Jun 21, 2019·Scientific Reports·Hussein MehidineDarine Abi Haidar
Jul 31, 2019·Biomedical Optics Express·João L LagartoAlexander R Lyon
Mar 17, 2019·Lasers in Medical Science·Khalid Salem Shibib, Dhuha Shaker
May 18, 2020·Scientific Reports·João L LagartoRiccardo Cicchi
Nov 12, 2020·PLoS Computational Biology·Doruk CakmakciA Ercument Cicek
Jan 14, 2021·Scientific Reports·Tyler W IorizzoAnna N Yaroslavsky
Feb 17, 2021·Scientific Reports·Hussein MehidineDarine Abi Haidar
Apr 9, 2021·Journal of Biophotonics·Peter W R ConnollyGerald S Buller
Jan 18, 2022·Journal of Biophotonics·Wen Qi ZhangShahraam Afshar Vahid
Mar 5, 2019··Melissa SkalaElizabeth S. Berge
Feb 27, 2019··Pascale VarletMatthieu Refregiers
Jan 2, 2018··Sally PlushJack R. Darby