Optical recording of vagal pathway formation in the embryonic brainstem

Autonomic Neuroscience : Basic & Clinical
Y Momose-Sato, Katsushige Sato

Abstract

Multiple-site optical recording with a fast voltage-sensitive dye, absorption dye NK2761, was used to study the developmental organization of functional synaptic networks in the vagal pathway. Glutamatergic excitatory postsynaptic potentials (EPSPs) evoked by vagus nerve stimulation was first detected from the nucleus of the tractus solitarius (NTS) at embryonic day 7 (E7) in chick embryos and E15 in rat embryos, when morphological differentiation of pre- and postsynaptic neurons is incomplete. When extracellular Mg2+ was removed, small EPSPs were elicited at E6 in chick embryos and E14 in rat embryos. These results suggest that synaptic function mediated by N-methyl-D-aspartate (NMDA) receptors is latently generated 1 day before the expression of glutamatergic EPSP. Functional synapses related to the glossophyaryngeal nerve appear to be generated at the same time as the vagus nerve, but their spatial distribution was different from that of the vagus nerve. We further investigated the development of second synaptic pathways from the NTS to higher centers, and found that neuronal circuits from the NTS are already generated when the primary afferents form functional synapses with NTS neurons.

References

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Citations

Dec 11, 2007·Clinical and Experimental Pharmacology & Physiology·Katsushige Sato, Yoko Momose-Sato
Feb 8, 2011·Respiratory Physiology & Neurobiology·Yoko Momose-Sato, Katsushige Sato
Mar 3, 2007·The European Journal of Neuroscience·Yoko Momose-SatoMasae Kinoshita
Dec 26, 2012·Neuroscience Letters·Yoko Momose-SatoKatsushige Sato
May 22, 2016·The European Journal of Neuroscience·Yoko Momose-Sato, Katsushige Sato
Sep 15, 2016·The Journal of Physiological Sciences : JPS·Katsushige Sato, Yoko Momose-Sato
Aug 18, 2018·The European Journal of Neuroscience·Yoko Momose-Sato, Katsushige Sato
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Dalbir S SandhuLewis R Roberts

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