PMID: 11945427DOI: 10.1016/0014-5793(70)80467-7Oct 1, 1970Paper

Optical rotatory dispersion properties of nucleic acid complexes with the oligopeptide antibiotics distamycin A and netropsin

FEBS Letters
C Zimmer, G Luck

Abstract

ORD measurements of nucleic acids in the presence of the oligopeptides netropsin and distamycin A have indicated association of the antibiotics with DNA and strong conformational changes of the DNA structure with specificity to AT-rich helical regions. The RNA conformation is relatively unaffected by these antibiotics. The results are explained in terms of a perturbation of the DNA secondary structure as well as of the chromophore system of the oligopeptides.

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Citations

Netropsin binding in five duplex-dimer DNA constructs as a function of size and distance between binding sites: circular dichroism and absorption spectroscopy.

Oct 28, 2009·European Biophysics Journal : EBJ·Lavanya Premvardhan, Jean-Claude Maurizot

Magnetic circular dichroism study of the binding of netropsin and distamycin A with DNA

Apr 30, 1980·Biochimica Et Biophysica Acta·C ZimmerW Guschlbauer

Nonintercalating DNA-binding ligands: specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material

Jan 1, 1986·Progress in Biophysics and Molecular Biology·C Zimmer, U Wähnert

Influence of netropsin and distamycin A on the secondary structure and template activity of DNA

Jul 29, 1971·European Journal of Biochemistry·C ZimmerH Venner

Binding of analogues of the antibiotics distamycin A and netropsin to native DNA. Effect of chomophore systems and basic residues of the oligopeptides on thermal stability, conformation and template activity of the DNA complexes

Mar 15, 1972·European Journal of Biochemistry·C ZimmerC Pitra

Effect of distamycin A on T4-DNA-directed RNA synthesis

Dec 2, 1974·European Journal of Biochemistry·B PuschendorfH Grunicke

Some structural requirements for the antibiotic action of distamycins

Sep 1, 1971·FEBS Letters·P ChandraM Ghione

Studies on the effect of distamycin A on the DNA dependent RNA polymerase system

May 7, 1971·Biochemical and Biophysical Research Communications·B PuschendorfH Grunicke

Studies on the interaction of distamycin A and its derivatives with DNA

Mar 15, 1972·Biochemical Pharmacology·F Zunino, A Di Marco

Thermal denaturation of distamycin A--DNA complexes as followed by hyperchromic spectra

Apr 1, 1980·Biophysical Chemistry·E Raukas, T Räim

Interaction between deoxyribonucliec acid and distamycin A studied by transformation in Bacillus subtilis.

Mar 1, 1973·Antimicrobial Agents and Chemotherapy·G MazzaA Siccardi

Congocidine and distamycin A, antipoxvirus antibiotics.

Jun 1, 1972·Antimicrobial Agents and Chemotherapy·Y BeckerZ Zakay-Rones

Linked lexitropsins and the in vitro inhibition of HIV-1 reverse transcriptase RNA-directed DNA polymerization: a novel induced-fit of 3,5 m-pyridyl bisdistamycin to enzyme-associated template-primer

Dec 3, 1996·Biochemistry·M E FilipowskyR E Dickerson

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