Optical sampling depth in the spatial frequency domain.

Journal of Biomedical Optics
Carole HayakawaVasan Venugopalan

Abstract

We present a Monte Carlo (MC) method to determine depth-dependent probability distributions of photon visitation and detection for optical reflectance measurements performed in the spatial frequency domain (SFD). These distributions are formed using an MC simulation for radiative transport that utilizes a photon packet weighting procedure consistent with the two-dimensional spatial Fourier transform of the radiative transport equation. This method enables the development of quantitative metrics for SFD optical sampling depth in layered tissue and its dependence on both tissue optical properties and spatial frequency. We validate the computed depth-dependent probability distributions using SFD measurements in a layered phantom system with a highly scattering top layer of variable thickness supported by a highly absorbing base layer. We utilize our method to establish the spatial frequency-dependent optical sampling depth for a number of tissue types and also provide a general tool to determine such depths for tissues of arbitrary optical properties.

References

Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·L R HirschJ L West
Jul 26, 2008·Nature Nanotechnology·Dan LiGordon G Wallace
Sep 6, 2008·Nature Nanotechnology·Yenny HernandezJonathan N Coleman
Apr 12, 2011·Journal of the American Chemical Society·Joshua T RobinsonHongjie Dai
May 10, 2011·Nature·Ming LiuXiang Zhang
Jun 17, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Umar KhanJonathan N Coleman
Dec 24, 2011·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Jeppe Revall Frisvad
Apr 17, 2012·Therapeutic Delivery·Dev Kumar ChatterjeeSunil Krishnan
Jan 24, 2013·Physical Chemistry Chemical Physics : PCCP·Zhiming LiuBiwen Yang
Oct 8, 2013·Applied and Environmental Microbiology·Andres Abin-FuentesKristala L J Prather
Dec 13, 2011·Journal of Chemical Theory and Computation·Alpeshkumar K MaldeAlan E Mark
May 10, 2011·Journal of Chemical Theory and Computation·Wei HuangWilfred F van Gunsteren
Mar 1, 2008·Journal of Chemical Theory and Computation·Berk HessErik Lindahl
Feb 18, 2016·Journal of Biomolecular Structure & Dynamics·Yahya SefidbakhtFatemeh Taheri
Sep 8, 2016·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Tianyu YeChangzhong Jiang

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