Optical techniques for the molecular imaging of angiogenesis.

European Journal of Nuclear Medicine and Molecular Imaging
Michel EisenblätterC Bremer

Abstract

The process of angiogenesis, an essential hallmark for tumour development as well as for several inflammatory diseases and physiological phenomena, is of growing interest for diagnosis and therapy in oncology. In the context of biochemical characterisation of key molecules involved in angiogenesis, several targets for imaging and therapy could be identified in the last decade. Optical imaging (OI) relies on the visualisation of near infrared (NIR) light, either its absorption and scattering in tissue (non-enhanced OI) or using fluorescent contrast agents. OI offers excellent signal to noise ratios due to virtually absent background fluorescence in the NIR range and is thus a versatile tool to image specific molecular target structures in vivo. This work intends to provide a survey of the different approaches to imaging of angiogenesis using OI methods in preclinical research as well as first clinical trials. Different imaging modalities as well as various optical contrast agents are briefly discussed.

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Jul 20, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Ambros J Beer, Xiaoyuan Chen
Oct 6, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Alexandru V KorotcovPaul C Wang
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Apr 22, 2015·Current Problems in Diagnostic Radiology·Roberto García-FigueirasDow-Mu Koh
Mar 12, 2021·International Journal of Radiation Biology·Rebecca A D'AlonzoMartin A Ebert

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