Optical Tweezers: Phototoxicity and Thermal Stress in Cells and Biomolecules

Micromachines
Alfonso Blázquez-Castro

Abstract

For several decades optical tweezers have proven to be an invaluable tool in the study and analysis of myriad biological responses and applications. However, as with every tool, they can have undesirable or damaging effects upon the very sample they are helping to study. In this review the main negative effects of optical tweezers upon biostructures and living systems will be presented. There are three main areas on which the review will focus: linear optical excitation within the tweezers, non-linear photonic effects, and thermal load upon the sampled volume. Additional information is provided on negative mechanical effects of optical traps on biological structures. Strategies to avoid or, at least, minimize these negative effects will be introduced. Finally, all these effects, undesirable for the most, can have positive applications under the right conditions. Some hints in this direction will also be discussed.

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Citations

Mar 1, 2020·Cells·Ruixue ZhuIgor Meglinski
Oct 11, 2019·Micromachines·Edison GerenaSinan Haliyo
Aug 28, 2020·Nature Communications·Michael BaudoinAlexis Vlandas
Feb 20, 2020·Micromachines·Philippa-Kate AndrewEbubekir Avci
Oct 20, 2020·Frontiers in Bioengineering and Biotechnology·Alfonso Blázquez-CastroJavier Santos
May 15, 2021·Optics Express·Meisam AskariAndrea Di Falco
Jun 27, 2021·Science Advances·Jingang LiYuebing Zheng
Jul 24, 2020·ACS Nano·Pooyath Lekshmy VenugopalanJoseph Wang
Dec 8, 2021·Light, Science & Applications·Xixi ChenBaojun Li

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Methods Mentioned

BETA
optical tweezers
chromosomal aberrations
transgenic

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