Optically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imaging

Photoacoustics
Shengtao LinMeng-Xing Tang

Abstract

We demonstrate a versatile phase-change sub-micron contrast agent providing three modes of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with optical activation, and 3) ultrasound contrast with acoustic activation. This agent, which we name 'Cy-droplet', has the following novel features. It comprises a highly volatile perfluorocarbon for easy versatile activation, and a near-infrared optically absorbing dye chosen to absorb light at a wavelength with good tissue penetration. It is manufactured via a 'microbubble condensation' method. The phase-transition of Cy-droplets can be optically triggered by pulsed-laser illumination, inducing photoacoustic signal and forming stable gas bubbles that are visible with echo-ultrasound in situ. Alternatively, Cy-droplets can be converted to microbubble contrast agents upon acoustic activation with clinical ultrasound. Potentially all modes offer extravascular contrast enhancement because of the sub-micron initial size. Such versatility of acoustic and optical 'triggerability' can potentially improve multi-modality imaging, molecularly targeted imaging and controlled drug release.

Citations

Jul 31, 2019·Biomedical Optics Express·Dmitry NevozhayKonstantin V Sokolov
Aug 9, 2019·BioMed Research International·Ksenia LoskutovaMorteza Ghorbani
Jul 12, 2019·Chemical Science·Javier Hernández-GilNicholas J Long
Jul 19, 2017·Physics in Medicine and Biology·Shengtao LinMeng-Xing Tang
Apr 10, 2018·Current Opinion in Chemical Biology·Aimen Zlitni, Sanjiv S Gambhir
Jun 14, 2021·Advances in Colloid and Interface Science·Marie Pierre Krafft, Jean G Riess
Aug 13, 2018·ACS Biomaterials Science & Engineering·Yue LiZhi-Yi Chen

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Methods Mentioned

BETA
confocal microscopy
dynamic light scattering

Software Mentioned

Matlab

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