PMID: 14638744Nov 26, 2003Paper

Opticin binds retinal growth hormone in the embryonic vitreous

Investigative Ophthalmology & Visual Science
E J SandersS Harvey

Abstract

Opticin is a small leucine-rich repeat proteoglycan that is abundant in several ocular tissues, including the vitreous. Like other proteoglycans, opticin may have the ability to bind and regulate the release of growth factors. Previous work has shown that isoforms of growth hormone (GH) are present in the embryonic retina, where they may act as a growth factor. The current study was conducted to investigate the possibility that opticin binds retinal GH in the vitreous of the chick embryo. The vitreous and retina of embryonic day-8 chicks were examined for the presence of opticin and GH, by Western immunoblot analysis, coimmunoprecipitation, and immunocytochemistry. Opticin associated with GH in the embryonic vitreous to produce a 60- to 62-kDa complex. Opticin and GH were also colocalized in the retina in retinal ganglion cells. The binding of retinal GH by opticin in the vitreous suggests that GH, secreted by the retinal ganglion cells, may be sequestered and concentrated in the vitreous and could act there as a paracrine differentiation factor in ocular development. During development, opticin could therefore regulate growth factor-like actions of retinal GH, both in the vitreous and the retinal ganglion cells. The physiologi...Continue Reading

Citations

Oct 26, 2010·Endocrine·S Harvey
May 26, 2005·Experimental Eye Research·Esmond J SandersSteve Harvey
Mar 1, 2008·Eye·M M Le Goff, P N Bishop
Apr 20, 2004·The British Journal of Ophthalmology·J V Forrester
Sep 29, 2006·The British Journal of Ophthalmology·David C AsshetonPaul S Hiscott
Oct 14, 2004·Anatomy and Embryology·Esmond J Sanders, Steve Harvey
Feb 16, 2012·General and Comparative Endocrinology·Steve HarveyEsmond J Sanders
Dec 28, 2010·General and Comparative Endocrinology·Esmond J SandersSteve Harvey
Jun 23, 2009·General and Comparative Endocrinology·Esmond J SandersSteve Harvey
Apr 7, 2009·General and Comparative Endocrinology·Esmond J SandersSteve Harvey
Jul 3, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Nhu NguyenYong Zhu
Feb 17, 2007·General and Comparative Endocrinology·Steve HarveyEsmond J Sanders
Jun 29, 2004·Progress in Retinal and Eye Research·Tapio IhanamäkiEero Vuorio
Apr 16, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Steve Harvey, Carlos G Martinez-Moreno
Aug 9, 2006·Experimental Eye Research·Esmond J SandersSteve Harvey
May 9, 2006·Experimental Eye Research·Magali M Le Goff, Paul N Bishop
Feb 11, 2014·Biochimica Et Biophysica Acta·Madalina V NastaseLiliana Schaefer
Mar 25, 2008·General and Comparative Endocrinology·Esmond J SandersSteve Harvey
Nov 19, 2013·General and Comparative Endocrinology·Carlos Martínez-MorenoSteve Harvey
Nov 17, 2010·Experimental Eye Research·Rachida A BouhenniDeepak P Edward
May 24, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Esmond J Sanders, Steve Harvey
Aug 11, 2012·The Journal of Biological Chemistry·Dragana NikitovicGeorge N Tzanakakis
Jul 25, 2021·International Journal of Molecular Sciences·Shermaine W Y LowShyam S Chaurasia

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