Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions

Physical Biology
Koichiro UriuLuis G Morelli

Abstract

Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillators. An important assumption in these studies is that cells can immediately interact with their new neighbors after arriving at a new location. However, intercellular interactions in cellular systems may need some time to become fully established. How movement affects synchronization in this situation has not been examined. Here, we develop a coupled phase oscillator model in which we consider cell movement and the gradual recovery of intercellular coupling experienced by a cell after movement, characterized by a moving rate and a coupling recovery rate, respectively. We find (1) an optimal moving rate for synchronization and (2) a critical moving rate above which achieving synchronization is not possible. These results indicate that the extent to which movement enhances synchrony is limited by a gradual recovery of coupling. These findings suggest that the ratio of time scales of movement and signaling recovery is critical for informa...Continue Reading

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Citations

Jan 13, 2016·Development, Growth & Differentiation·Koichiro Uriu
Jul 17, 2014·Biophysical Journal·Koichiro Uriu, Luis G Morelli
Jun 3, 2014·Seminars in Cell & Developmental Biology·Koichiro UriuAndrew C Oates
Nov 27, 2016·Arthropod Structure & Development·Bo-Kai Liao, Andrew C Oates
Oct 27, 2016·Chaos·Naoya FujiwaraAlbert Díaz-Guilera
Oct 3, 2014·PLoS Computational Biology·Hendrik B TiedemannMartin Hrabě de Angelis
Jun 20, 2017·Development, Growth & Differentiation·Koichiro Uriu, Luis G Morelli
Jan 20, 2018·Physical Review. E·Gabriela PetrungaroLuis G Morelli
May 14, 2016·Physical Review. E·Robert GroßmannMarkus Bär
Jul 25, 2019·Physical Review. E·Gabriela PetrungaroLuis G Morelli
Jan 6, 2017·Journal of the Royal Society, Interface·Justine Dattani, Mauricio Barahona
Feb 10, 2021·Journal of the Royal Society, Interface·Supriya BajpaiMandar M Inamdar
Mar 31, 2019·Developmental Biology·Rajasekaran Bhavna
Jun 1, 2021·Interface Focus·Lara Busby, Benjamin Steventon

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