Optimal clearance of Sporothrix schenckii requires an intact Th17 response in a mouse model of systemic infection

Immunobiology
Lucas Souza FerreiraIracilda Zeppone Carlos

Abstract

The discovery of Th17 cells, along with many other Th cell subsets in the recent years, has expanded the Th1/Th2 paradigm that had persisted since its proposition by Mosmann in 1986. Defined by the characteristic expression of the transcription factor retinoic-related orphan receptor γt (RORγt) and production of IL-17A (IL-17), Th17 cells are powerful inducers of tissue inflammation with a recognized role against extracellular bacteria and fungi. Despite this, the interest in their study came from the pivotal role they play in the development and maintenance of major chronic inflammatory conditions such as multiple sclerosis, rheumatoid arthritis and Crohn's disease, hence they have been the target of promising new anti-Th17 therapies. Accordingly, the identification of opportunistic pathogens whose clearance relies on the Th17 response is of huge prophylactic importance. As shown here for the first time, this applies to Sporothrix schenckii, a thermo-dimorphic fungus and the causative agent of sporotrichosis. Our results show that both Th17 and Th1/Th17 mixed cells are developed during the S. schenckii systemic mice infection, which also leads to augmented production of IL-17 and IL-22. Also, by using an antibody-mediated IL-2...Continue Reading

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Citations

Apr 28, 2016·Current Microbiology·Carlos A Alba-FierroEstela Ruiz-Baca
Feb 1, 2017·Immunology·Amanda Costa GonçalvesIracilda Zeppone Carlos
Nov 1, 2017·Medical Mycology·Francine Alessandra ManenteIracilda Zeppone Carlos
Nov 20, 2018·Journal of Medical Microbiology·Luana RossatoSandro Rogério de Almeida
Dec 1, 2018·PloS One·Luisa Helena Monteiro de MirandaRegina Hofmann-Lehmann
Aug 31, 2017·PLoS Neglected Tropical Diseases·Paula Portella Della TerraZoilo Pires de Camargo
Nov 26, 2015·Mycopathologia·Danielle Cardoso Geraldo MaiaIracilda Zeppone Carlos
Aug 2, 2018·Journal of Fungi·Fatima Conceição-Silva, Fernanda Nazaré Morgado
Jan 16, 2019·Journal of Fungi·Flavio Queiroz-TellesGil Benard
May 26, 2018·Journal of Fungi·Alexander Batista-DuharteIracilda Zeppone Carlos
Apr 4, 2021·International Journal of Molecular Sciences·Alexander Batista-DuharteSalvador Francisco Aliño
Jun 3, 2021·International Journal of Molecular Sciences·Yu SawadaMotonobu Nakamura
Aug 7, 2021·Pathogens·Estela Ruiz-BacaConchita Torriello

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