PMID: 11342916May 9, 2001Paper

Optimal combinations of systematic sextant and laterally directed biopsies for the detection of prostate cancer

The Journal of Urology
J L GoreKevin M Slawin

Abstract

The standard sextant protocol for obtaining transrectal ultrasound guided biopsy of the prostate has been shown to underestimate the presence of prostate cancer. Studies have demonstrated an increased cancer detection rate with additional laterally directed biopsies. We compared the sensitivity of individual biopsy cores and evaluated combinations of these cores to identify an optimal biopsy strategy. A total of 396 consecutive patients underwent biopsy of the lateral peripheral zone in addition to standard sextant biopsy. The cancer detection rate for each biopsy core was calculated. The sensitivity of different combinations of biopsy cores was compared with those of standard sextant biopsies and with a 12 core biopsy protocol that combined the standard sextant biopsy with a complete set of laterally directed cores. Cancer was detected in 160 of 396 (40.3%) patients. Of the possible combinations of biopsy cores a strategy that included laterally directed cores at the base, mid gland and apex of the prostate with mid lobar base and apical cores detected 98.5% of cancers. The detection rate of this 10 core biopsy regimen was significantly better than that of the standard sextant protocol (p < or =0.001), and was equivalent to th...Continue Reading

References

Aug 1, 1988·The American Journal of Surgical Pathology·J E McNeal
Jan 1, 1993·British Journal of Urology·H J StrickerW D Belville
Aug 26, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·Y GotoP T Scardino
May 1, 1999·Urology·M E ChenD Johnston
Jul 14, 2000·The Journal of Urology·V RaveryL Boccon-Gibod

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Citations

Mar 1, 2012·International Urology and Nephrology·Luca CarmignaniAugusto Maggioni
Jun 27, 2002·Current Urology Reports·Timothy Donahue, Judd Moul
May 27, 2004·Current Urology Reports·Eduardo I CantoKevin M Slawin
Feb 24, 2011·Current Urology Reports·David A Levy, J Stephen Jones
Oct 18, 2012·Current Urology Reports·Ryan K Berglund, J Stephen Jones
Jan 5, 2012·Pathology Oncology Research : POR·Luca CarmignaniClaudio Clemente
Aug 6, 2002·European Urology·Bob DjavanAlexandre R Zlotta
Jun 20, 2003·European Urology·Jane L BoddyPeter R Malone
Jul 15, 2003·Urologic Oncology·Joseph C Presti
Oct 17, 2003·The New England Journal of Medicine·Mark A Rubin, Philip W Kantoff
Apr 7, 2010·Journal of Endourology·Bharat Gowardhan, Damian Greene
Nov 30, 2011·Journal of Endourology·Seung Hwan LeeByung Ha Chung
Dec 3, 2002·The American Journal of Surgical Pathology·R BeachM B Amin
Aug 23, 2006·Topics in Magnetic Resonance Imaging : TMRI·Steven J HakerClare M C Tempany
Aug 13, 2005·The American Journal of Surgical Pathology·Cory SchlesingerKenneth A Iczkowski
Mar 13, 2010·Future Oncology·Giovanni LughezzaniPierre I Karakiewicz
Mar 7, 2009·World Journal of Gastroenterology : WJG·Panagiotis KatsinelosKostas Mimidis
Jan 9, 2010·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hoon ChoiVipul R Patel
Mar 30, 2007·Radiology·Hedvig HricakPeter T Scardino
Jun 9, 2014·World Journal of Urology·Vincenzo ScattoniFrancesco Montorsi
Sep 27, 2008·Journal of the Chinese Medical Association : JCMA·Chih-Chieh LinKuang-Kuo Chen
Apr 15, 2014·The Urologic Clinics of North America·Marc A BjurlinSamir S Taneja
Nov 5, 2013·The Urologic Clinics of North America·Mohamed T Ismail, Leonard G Gomella
Oct 28, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Luca CarmignaniMarco Pavesi

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