Optimal configurations of spatial scale for grid cell firing under noise and uncertainty

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Benjamin W TowseNeil Burgess

Abstract

We examined the accuracy with which the location of an agent moving within an environment could be decoded from the simulated firing of systems of grid cells. Grid cells were modelled with Poisson spiking dynamics and organized into multiple 'modules' of cells, with firing patterns of similar spatial scale within modules and a wide range of spatial scales across modules. The number of grid cells per module, the spatial scaling factor between modules and the size of the environment were varied. Errors in decoded location can take two forms: small errors of precision and larger errors resulting from ambiguity in decoding periodic firing patterns. With enough cells per module (e.g. eight modules of 100 cells each) grid systems are highly robust to ambiguity errors, even over ranges much larger than the largest grid scale (e.g. over a 500 m range when the maximum grid scale is 264 cm). Results did not depend strongly on the precise organization of scales across modules (geometric, co-prime or random). However, independent spatial noise across modules, which would occur if modules receive independent spatial inputs and might increase with spatial uncertainty, dramatically degrades the performance of the grid system. This effect of s...Continue Reading

References

Apr 1, 1976·Experimental Neurology·J O'Keefe
Jun 1, 1994·Journal of Computational Neuroscience·E Salinas, L F Abbott
Oct 25, 2002·Neural Computation·M BethgeK Pawelzik
Jun 10, 2005·Neuron·Angela J Yu, Peter Dayan
Jun 21, 2005·Nature·Torkel HaftingEdvard I Moser
May 18, 2006·Reviews in the Neurosciences·Caswell BarryNeil Burgess
Oct 3, 2006·Current Opinion in Neurobiology·Michael E Hasselmo
Jan 16, 2007·Neural Networks : the Official Journal of the International Neural Network Society·Anatoli Gorchetchnikov, Stephen Grossberg
Feb 27, 2007·Nature·Marianne FyhnEdvard I Moser
May 9, 2007·Nature Neuroscience·Caswell BarryKathryn J Jeffery
Jun 29, 2007·Hippocampus·Neil BurgessJohn O'Keefe
Jul 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ila R FieteTed Brookings
Nov 21, 2008·Hippocampus·Vegard Heimly BrunMay-Britt Moser
Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Colin LeverNeil Burgess
Sep 13, 2011·Nature Neuroscience·Sameet Sreenivasan, Ila Fiete
Mar 1, 2012·Frontiers in Neural Circuits·Caswell BarryMichael E Hasselmo
May 19, 2012·Neural Computation·Alexander MathisMartin Stemmler
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Caswell BarryNeil Burgess
Dec 12, 2012·Nature·Hanne StensolaEdvard I Moser
Jul 16, 2013·Nature Neuroscience·Kijung YoonIla R Fiete
Sep 17, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Alexander MathisMartin B Stemmler

❮ Previous
Next ❯

Citations

Apr 4, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel Bush, Neil Burgess
May 3, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher P Burgess, Neil Burgess
Sep 4, 2015·ELife·Xue-Xin WeiVijay Balasubramanian
Oct 21, 2016·Neural Computation·Yongseok Yoo, Woori Kim
Apr 17, 2014·Current Biology : CB·C Barry, N Burgess
Apr 21, 2016·The Journal of Physiology·Florian RaudiesMichael E Hasselmo
Jan 9, 2018·PLoS Computational Biology·Lajos Vágó, Balázs B Ujfalussy
Feb 16, 2019·PLoS Computational Biology·Ardi TampuuRaul Vicente
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tom HartleyJohn O'Keefe
Nov 20, 2019·Nature Human Behaviour·Jacob L S BellmundChristian F Doeller
Feb 18, 2020·Hippocampus·Daniel Bush, Neil Burgess
Feb 21, 2019·Nature Communications·Pierre-Yves JacobFrancesca Sargolini

❮ Previous
Next ❯

Software Mentioned

atlab
Mathworks

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Hugh T BlairJason Cong
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Daniel Bush, Neil Burgess
Proceedings of the National Academy of Sciences of the United States of America
C BarryNeil Burgess
© 2021 Meta ULC. All rights reserved