Optimal cut-off points of fasting plasma glucose for two-step strategy in estimating prevalence and screening undiagnosed diabetes and pre-diabetes in Harbin, China

PloS One
Chundan BaoHongyuan Li

Abstract

To identify optimal cut-off points of fasting plasma glucose (FPG) for two-step strategy in screening abnormal glucose metabolism and estimating prevalence in general Chinese population. A population-based cross-sectional study was conducted on 7913 people aged 20 to 74 years in Harbin. Diabetes and pre-diabetes were determined by fasting and 2 hour post-load glucose from the oral glucose tolerance test in all participants. Screening potential of FPG, cost per case identified by two-step strategy, and optimal FPG cut-off points were described. The prevalence of diabetes was 12.7%, of which 65.2% was undiagnosed. Twelve percent or 9.0% of participants were diagnosed with pre-diabetes using 2003 ADA criteria or 1999 WHO criteria, respectively. The optimal FPG cut-off points for two-step strategy were 5.6 mmol/l for previously undiagnosed diabetes (area under the receiver-operating characteristic curve of FPG 0.93; sensitivity 82.0%; cost per case identified by two-step strategy ¥261), 5.3 mmol/l for both diabetes and pre-diabetes or pre-diabetes alone using 2003 ADA criteria (0.89 or 0.85; 72.4% or 62.9%; ¥110 or ¥258), 5.0 mmol/l for pre-diabetes using 1999 WHO criteria (0.78; 66.8%; ¥399), and 4.9 mmol/l for IGT alone (0.74; 62...Continue Reading

References

Nov 20, 1998·The American Journal of Cardiology·F H Messerli, E Grossman
Aug 30, 2000·Diabetes Research and Clinical Practice·C ItoH Sasaki
May 10, 2001·JAMA : the Journal of the American Medical Association·F de VegtR J Heine
Mar 1, 2003·Diabetes Care·UNKNOWN DECODE Study Group, European Diabetes Epidemiology Group
Jan 30, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·UNKNOWN Diabetes Prevention Program Research Group
Aug 29, 2009·Diabetes Research and Clinical Practice·Shaoyan ZhangYonghong Zhang
Mar 26, 2010·The New England Journal of Medicine·Wenying YangUNKNOWN China National Diabetes and Metabolic Disorders Study Group
Mar 27, 2010·Journal of the American College of Cardiology·Earl S FordChaoyang Li
Jun 25, 2010·The New England Journal of Medicine·Zumin Shi
Jan 14, 2011·Diabetes Care·UNKNOWN American Diabetes Association
Jan 7, 2011·Diabetes Research and Clinical Practice·Altan OnatHüsniye Yüksel

❮ Previous
Next ❯

Citations

Jun 1, 2016·Diabetes Research and Clinical Practice·Xiaoyan GuoKaijun Niu
Feb 21, 2018·European Journal of Public Health·Laura PaalanenHanna Tolonen
Aug 22, 2020·Reports of Biochemistry & Molecular Biology·Fatemeh SadabadiHabibollah Esmaeili
Mar 3, 2020·The Korean Journal of Internal Medicine·Jin-Hee LeeUNKNOWN Korean Diabetes Prevention Study Investigators

❮ Previous
Next ❯

Software Mentioned

DECODA
SAS

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.