Optimal cutoff level of serum squamous cell carcinoma antigen to detect recurrent cervical squamous cell carcinoma during post-treatment surveillance

Obstetrics & Gynecology Science
Jinju Oh, Jin Young Bae

Abstract

The objective of this study was to determine the optimal cutoff level of serum squamous cell carcinoma antigen (SCC-Ag) to detect recurrent cervical squamous cell carcinoma during post-treatment surveillance. Between January 2000 and July 2014, a total of 158 women with cervical squamous cell carcinoma were treated with radiotherapy with or without concurrent chemotherapy at our department. A total of 1,550 serum SCC-Ag tests performed during post-treatment surveillance of the 158 patients were included in this retrospective study. During post-treatment surveillance, 53 patients were diagnosed as having recurrent cervical cancer based on biopsy or a radiological test showing progression of a lesion. Receiver operating characteristic (ROC) curve for serum SCC-Ag to diagnose recurrent cervical squamous cell carcinoma showed that the area under the ROC curve was 0.914 (95% confidence interval, 0.887-0.942; P<0.001). The best cutoff value for serum SCC-Ag to obtain the highest Youden's index was ≥2 ng/mL (sensitivity, 80.2%; specificity, 94.6%). Serum SCC-Ag test was helpful in detecting recurrent cervical squamous cell carcinoma during post-treatment surveillance, and the optimal cutoff value was ≥2 ng/mL. The researchers recommen...Continue Reading

References

Nov 1, 1989·European Journal of Cancer & Clinical Oncology·W MeierH Hepp
Aug 1, 1987·American Journal of Obstetrics and Gynecology·E K SenekjianA L Herbst
Oct 1, 1994·Gynecologic Oncology·R L ColemanF N Rutledge
Oct 12, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H-G StraussH Koelbl
Mar 26, 2003·International Journal of Radiation Oncology, Biology, Physics·Jun-Sang KimMoon-June Cho
Feb 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P MoriceD Castaigne
Mar 31, 2004·The Journal of Thoracic and Cardiovascular Surgery·Masaki AnrakuUNKNOWN Metastatic Lung Tumor Study Group of Japan
Jan 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Anurag K SinghMatthew A Powell
Mar 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nathalie Reesink-PetersAte G J van der Zee
Jul 15, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·I OginoT Inoue
Nov 28, 2006·International Journal of Radiation Oncology, Biology, Physics·Yuzuru NiibeUNKNOWN Japanease Isolated Para-Aortic Lymph Node Recurrence of Uterine Cervical Carcinoma Study Group
Aug 11, 2007·International Journal of Radiation Oncology, Biology, Physics·Franca ForniGiovanni Scambia
Apr 28, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Vanna ZanagnoloFabio Landoni
Jun 30, 2009·Gynecologic Oncology·Laurie ElitUNKNOWN Gynecology Cancer Disease Site Group
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jul 25, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Paolo ZolaVesna Kesic
Aug 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Beata KotowiczMaria Kowalska

❮ Previous
Next ❯

Methods Mentioned

BETA
hysterectomy
biopsy

Software Mentioned

SPSS

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.