Optimal cutoff of mean corpuscular volume (MCV) for screening of alpha-thalassemia 1 trait

The Journal of Obstetrics and Gynaecology Research
Chanhathai NunchaiTheera Tongsong

Abstract

To identify the optimal cutoff of mean corpuscular volume (MCV) for screening of alpha-thalassemia 1 trait. The database of pregnant women who attended antenatal care clinic at Department of Obstetrics and Gynecology, Chiang Mai University during January 1st, 2015 to December 31st, 2017 was accessed and reviewed. A total of 1264 cases who had MCV ≤80 fL and met the inclusion criteria were enrolled to the study. Cases with hemoglobin level ≤10.0 gm/dL, iron deficiency anemia, chronic medical diseases and other types of thalassemia trait except alpha-thalassemia 1 trait were excluded. After exclusion, 438 cases were available for analysis. Of them, 139 were alpha-thalassemia 1 trait. Based on the receiver operating characteristic curves, the best cutoff value of MCV for screening of alpha-thalassemia 1 trait was ≤76.15 fL, giving 100% sensitivity, and 60.9% specificity with the area under curve of 0.925. Compared to the conventional cutoff (≤80 fL), the new cutoff gave much less false positive tests (117 vs 299 cases), whereas capability to detect alpha-thalassemia 1 trait was the same. With the new MCV cutoff (≤76.15 fL) as a secondary cutoff for screening alpha-thalassemia 1 carrier, a substantial number of positive cases requi...Continue Reading

References

Aug 25, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Supatra SirichotiyakulTheera Tongsong
Mar 11, 2005·Current Opinion in Obstetrics & Gynecology·Tse N LeungTony Kh Chung
May 27, 2005·The Journal of Obstetrics and Gynaecology Research·Supatra SirichotiyakulTheera Tongsong
Jun 26, 2008·Annals of Hematology·Kanokwan SanchaisuriyaPattara Sanchaisuriya
May 30, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Chanane WanapirakTheera Tongsong
Jul 14, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Supatra SirichotiyakulTheera Tongsong
Apr 5, 2013·Prenatal Diagnosis·Theera TongsongSavitree Pranpanus
May 4, 2015·Journal of Clinical Pathology·Nasrollah Saleh-GohariHassan Karimi-Maleh
Dec 14, 2017·International Journal of Molecular Sciences·Diego Velasco-RodríguezPilar Llamas-Sillero

Related Concepts

Chronic Disease
Drug Carriers
Gynecology
Hemoglobin
Obstetrics Department
Pregnant Women
Prenatal Care
Iron Deficiency Anemia
False Positive
Clinic

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